| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We hypothesized that intra-peritoneal injected mesothelial cells which usually played a central role in the restoration of the peritoneum tissue may accelerate peritoneal repair in chlorhexidine-induced peritoneal fibrosis rats.However, mesothelial transplantation aggravated peritoneal fibrosis and delayed the restoration of tissue.
According to the results, we analyzed serial morphological changes of peritoneum and transplanted mesothelial cells and expression of inflammatory cytokines and growth factors in peritoneum. Transplanted mesothelial cells transformed to fibroblastic cells stimulated by inflammatory cytokines and various growth factors in injured peritoneal tissue through activation of RAS/MAPK system. And then they secreted by oneself more inflammatory cytokines and fibrosis promoting factors and aggravated peritoneal fibrosis.
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