Roles of hydrogen peroxide-inducible clone-5 on vascular disease in chronic kidney disease

• Project/Area Number: 24591241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Showa University
• Principal Investigator: HIROKAZU Honda 昭和大学, 医学部, 准教授 (70297000)
• Co-Investigator(Kenkyū-buntansha): AKIRA Miyazaki 昭和大学, 医学部生化学教室, 教授 (70253721)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 細胞接着斑蛋白質 / 血管石灰化 / 動脈硬化 / 慢性腎臓病 / HIC-5 / 血管平滑筋細胞 / 血管内皮細胞 / 平滑筋細胞 / 石灰化 / 形質転換

Outline of Final Research Achievements

Chronic kidney disease (CKD) is a risk factor for cardiovascular disease. Purpose of the study was to assess roles of hydrogen peroxide-inducible clone-5 (HIC-5) on vascular disease in CKD.
Expressions of HIC -5 were increased at vascular smooth muscles cells (VSMC) and on endothelial lesions of carotid arteries at autopsy samples from patients with CKD. HIC-5 was over expressed in process of VSMC calcification in cell culture with phosphate overload and was associated with interaction between macrophages and vascular endothelial cells in vitro model. Moreover, HIC-5 was associated with development and progression of atherosclerotic lesions of animal model.

Research Products

• [Journal Article] Role of HIC-5 in the formation of microvilli-like structures and the monocyte-endotherial interaction that accelerates atherosclerosis (2015)
  • Author(s): Shigeko Arita-Okubo, et al
  • Journal Title: Cardiovasc Res Volume: 105 Issue: 3 Pages: 361-371
  • DOI: 10.1093/cvr/cvv003
  • Peer Reviewed / Open Access