| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The aquaporin-11 (AQP11) is a water channel expressed at the intracellular organelle. The AQP11 null mice are fatal due to kidney failure caused by polycystic kidneys around one month after birth. Before developing polycystic kidneys, their proximal tubular cells have multiple vesicles. We have identified enhanced autophagy, a self-degradative process in the proximal tubules of AQP11 null mice as well as their primary cultured cells with visualization of activated LC3, a marker for autophagy. Our results suggest that the manipulation of autophagy will be a promising treatment modality for polycystic kidneys.
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