| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Neuromyelitis optica (NMO) is an autoimmune inflammatory disease by anti-aquaporin 4 (AQP4) antibody mainly targeting against astrocyte foot processes in the central nervous system (CNS). However, the mechanism of demyelination is not well resolved.
In this project, we have studied the mechanism of astrocytopathy and demyelination by passive transfer model of AQP4 antibody on rodent experimental encephalomyelitis. This model is featured by highly reproducible and typical astrocytopathy lesion like post-mortem cases of NMO. It is revealed that demyelination is secondarily produced after the induction of astrocytopathy lesion, and the lesion development is higly associated with infiltration of inflammatory cells, especially neutrophil.
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