| Project/Area Number |
24591256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gifu University |
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Principal Investigator |
INUZUKA Takashi 岐阜大学, 医学(系)研究科(研究院), 教授 (50184734)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Akio 岐阜大学, 大学院医学系研究科, 准教授 (00362161)
YANO Takeo 三重大学, 地域イノベーション学研究科, 教授 (00569197)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アルツハイマー型認知症 / 抗血管内皮抗体 / 抗神経抗体 / バイオマーカー / プロテオミクス / 二次元ブロット法 / 質量分析 / 抗Tom40抗体 |
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| Outline of Final Research Achievements |
We identified novel autoantibodies in serum samples from patients with Alzheimer’s diseases. To identify these novel antibodies, we employed two-dimensional immunoblotting using human neuroblastoma cells, human brain microvascular endothelial cells, or rat brain homogenate as the antigen source. As a result, we identified autoantibodies against Phosphatidylinositol transfer protein alpha isoform and Mitochondrial import receptor subunit TOM40 homolog in sera from patients with Alzheimer’s diseases. There are several reports describing that these autoantigens may be associated with Alzheimer’s diseases. Further studies are needed to establish whether our identified autoantibodies could be useful biomarkers of Alzheimer’s diseases.
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