| Project/Area Number |
24591265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Satoshi 九州大学, 大学病院, 助教 (20596390)
MATSUSE Dai 九州大学, 大学病院, 助教 (70596395)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経免疫 / 自己抗体 / 慢性炎症性脱髄性多発根ニューロパチー / ランビエ絞輪 / 慢性炎症性多発根神経炎 / Neurofascin / 新規自己抗原 / 中枢末梢連合脱髄症 / ELISA / cell-based assay / 慢性炎症性脱髄性多発根神経炎 / ウエスタンブロット / セルベーストアッセイ |
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| Outline of Final Research Achievements |
In this study, we clarified that 18% of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) were positive for antibodies against neurofascin 155 (NF155), which is cell-adhesion molecule and located around nodes of Ranvier. The anti-NF155 antibody-positive CIDP patients had significantly younger onset age, more frequent occurrence of distal acquired demyelinating symmetric phenotype and tremor, longer distal and F wave latencies, greater cerebrospinal fluid protein levels, and greater cervical root diameters than anti-NF155 antibody-negative CIDP patients. Marked symmetric hypertrophy of cervical and lumbosacral roots/plexuses was present in all the anti-NF155 antibody-positive CIDP patients examined by MRI neurography. A part of the anti-NF155 antibody-positive CIDP patients also had demyelination in the central nervous system, which suggested that this autoantibody could induce combined central and peripheral demyelination.
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