Analysis of chronic inflammation in the Alzheimer's brain and development of the treatment for the suppression of T cell activation.
| Project/Area Number |
24591266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Saga University |
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Principal Investigator |
HARA Hideo 佐賀大学, 医学部, 教授 (00260381)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルツハイマー病 / 脳炎 / 炎症性サイトカイン / リンパ球 / 免疫抑制因子 / 老人斑 / ワクチン / 抗炎症作用 / サイトカイン / アミロイドベータ蛋白 / 脳炎症 / T細胞 / 免疫抑制蛋白 |
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| Outline of Final Research Achievements |
Aβ vaccines were developed for the treatment of Alzheimer’s disease. However, clinical trial of active immunization of Aβ peptides showed that 6% of patients suffered from meningoencephalitis. It is thought that the cause of meningoencephalitis may be mainly due to the CD4+ T cells reactive to Aβ. We found new function of SPARC/osteonectin, extracellular cysteine-rich matrix protein as immune-suppressant, and we tried to suppress inflammation under the conditions of Aβ peptide-active immunization and transfer of Aβ－reactive encephalitogenic T cells to APP transgenic mice by SPARC/osteonectin. SPARC/osteonectin suppressed infiltrations of lymphocytes into the brain and also down-regulated the expression of inflammatory cytokines such as TNF-α.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Basal Ganglia Cerebral Microbleeds and Global Cognitive Function: The Kashima Scan Study.2014
Author(s)
Yakushiji Y, Noguchi T, Charidimou A, Eriguchi M, Nishihara M, Hara M, Nanri Y, Horikawa E, Nishiyama M, Werring DJ, Hara H.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 24
Issue: 2
Pages: 431-439
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis2014
Author(s)
Tabata, E. Masuda, M. Eriguchi, M. Yokoyama, M. Takahashi, Y. Tanaka, K. Yukitake, M, Horikawa, E. Hara, H
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Journal Title
Eur Neurol
Volume: 71
Issue: 1-2
Pages: 42-48
DOI
Related Report
Peer Reviewed
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[Journal Article] Refractory acute disseminated encephalopathy with anti-galactocerebroside antibody.2013
Author(s)
Samukawa M, Hirano M, Tsugawa J, Sakamoto H, Tabata E, Takada K, Kuwahara M, Suzuki S, Kitada M, Yamada T, Hara H, Tsuboi Y, Nakamura Y, Kusunoki S.
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Journal Title
Neuroscience Research
Volume: 74
Issue: 3-4
Pages: 284-289
DOI
Related Report
Peer Reviewed
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[Journal Article] Distributional impact of brain microbleeds on global cognitive function in adults without neurological disorder.2012
Author(s)
Yakushiji Y, Noguchi T, Hara M, Nishihara M, Eriguchi M, Nanri Y, Nishiyama M, Hirotsu T, Nakajima J, Kuroda Y, Hara.H.
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Journal Title
Stroke
Volume: 43
Pages: 1800-1805
Related Report
Peer Reviewed
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[Presentation] Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis.2013
Author(s)
Tabata, Masanori Masuda,Makoto Eriguchi, Masatoshi Yokoyama, Yoshiyuki Takahashi, Keiko Tanaka, Motohiro Yukitake, Etuo Horikawa,Hideo Hara,
Organizer
XXIth World Congress of Neurology
Place of Presentation
Wien, Austria
Related Report
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