Therapeutic approach for ER stress in the pathogenesis of ALS
Project/Area Number |
24591269
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kumamoto University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
ERA Takumi 熊本大学, 発生医学研究所, 教授 (00273706)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 筋萎縮性側索硬化症 / iPS細胞 / 遠位型ミオパチー / 小胞体ストレス / 運動ニューロン |
Outline of Final Research Achievements |
We have established iPS cell lines derived from sporadic and familial ALS (SOD1, FUS, and MATR3 mutations) patients. We induced these iPS cells into motor neurons, and examined the expression of endoplasmic reticulum (ER) stress-related molecules. In this experiment, some of ER stress-related molecules including ER chaperones, transcription factors, and pro-apoptotic factors were upregulated in the mutant FUS-expressing cells. However, a few molecules were affected uniformly in the different types of the FUS mutations. A further examination would be required to confirm the results. We also needs to consider limitations under the experiments using iPS cells, such as variability among iPS clones and developmental condition into motor neurons.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Clinicopathological features of the first Asian family having vocal cord and pharyngeal weakness with distal myopathy due to a MATR3 mutation2015
Author(s)
Yamashita S, Mori A, Nishida Y, Kurisaki R, Tawara N, Nishikami T, Misumi Y, Ueyama H, Imamura S, Higuchi Y, Hashiguchi A, Higuchi I, Morishita S, Yoshimura J, Uchino M, Takashima H, Tsuji S, Ando Y.
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Journal Title
Neuropathology and Applied Neurobiology
Volume: 41
Pages: 276-277
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Reply to comments on 'gait disturbance due to foot drop is refractory to treatment in nonsystemic vasculitic neuropathy'.2015
Author(s)
Hirahara T, Yamashita S, Misumi Y, Kawakami K, Hori H, Honda S, Watanabe M, Ikeda T, Yamashita T, Maeda Y, Ando Y.
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Journal Title
Eur Neurol
Volume: 73
Pages: 80-80
DOI
Related Report
Peer Reviewed
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[Journal Article] Osteopontin-integrin αvβ3 axis is crucial for 5-fluorouracil resistance in oral squamous cell carcinoma2015
Author(s)
Nakamura T, Shinriki S, Jono H, Ueda M, Nagata M, Guo J, Hayashi M, Yoshida R, Ota T, Ota K, Kawahara K, Nakagawa Y, Yamashita S, Nakayama H, Hiraki A, Shinohara M, Ando Y.
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Journal Title
FEBS Letter
Volume: 589
Pages: 231-239
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells.2015
Author(s)
Nakamura T, Shinriki S, Jono H, Guo J, Ueda M, Hayashi M, Yamashita S, Zijlstra A, Nakayama H, Hiraki A, Shinohara M, Ando Y.
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Journal Title
Oncotarget
Volume: 6
Pages: 1008-1019
Related Report
Peer Reviewed
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[Journal Article] Gait disturbance due to foot drop is refractory to treatment in nonsystemic vasculitic neuropathy.2014
Author(s)
Hirahara T, Yamashita S, Misumi Y, Kawakami K, Hori H, Honda S, Watanabe M, Ikeda T, Yamashita T, Maeda Y, Ando Y
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Journal Title
Eur Neurol.
Volume: 71(3-4)
Pages: 180-186
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.2014
Author(s)
Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, Kuratsu J, Yamashita S, Ueda M, Li JD, Ando Y, Jono H.
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Journal Title
Oncotarget
Volume: 5
Pages: 6353-6364
Related Report
Peer Reviewed / Open Access
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[Journal Article] Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration2014
Author(s)
Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y
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Journal Title
J Neurol
Volume: 261
Pages: 2209-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Drastic therapy for listerial brain abscess involving combined hyperbaric oxygen therapy and antimicrobial agents.2014
Author(s)
Nakahara K, Yamashita S, Ideo K, Shindo S, Suga T, Ueda A, Honda S, Hirahara T, Watanabe M, Yamashita T, Maeda Y, Yonemochi Y, Takita T, Ando Y.
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Journal Title
J Clin Neurol
Volume: 10
Pages: 358-62
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood2014
Author(s)
Fujie Y, Fusaki N, Katayama T, Hamasaki M, Soejima Y, Soga M, Ban H, Hasegawa M, Yamashita S, Kimura S, Suzuki S, Matsuzawa T, Akari H, Era T
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Journal Title
PLoS ONE
Volume: 9
Pages: 113052-113052
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Stromal Expression of Neutrophil Gelatinase-Associated Lipocalin Correlates with Poor Differentiation and Adverse Prognosis in Oral Squamous Cell Carcinoma.2014
Author(s)
Shinriki S., Jono H., Ueda M., Obayashi K., Nakamura T., Ota K., Ota T., Sueyoshi T., Guo J., Hayashi M., Hiraki A., Nakayama H., Yamashita S., Shinohara M., & Ando Y.
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Journal Title
Histopathology
Volume: 64
Pages: 353-364
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of CYLD downregulation in breast cancer.2014
Author(s)
Hayashi M, Jono H, Shinriki S, Nakamura T, Guo J, Sueta A, Tomiguchi M, Fujiwara S, Yamamoto-Ibusuki M, Murakami K, Yamashita S, Yamamoto Y, Li JD, Iwase H, Ando Y.
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Journal Title
Breast Cancer Res. Treat.
Volume: 143
Pages: 447-457
DOI
Related Report
Peer Reviewed
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[Journal Article] Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis.2013
Author(s)
Uchino M, Yamashita S, Uchino K, Mori A, Hara A, Suga T, Hirahara T, Koide T, Kimura E, Yamashita T, Ueda A, Kurisaki R, Suzuki J, Honda S, Maeda Y, Hirano T, Ando Y
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Journal Title
Clin Neurol Neurosurg.
Volume: 115(5)
Pages: 603-6
DOI
Related Report
Peer Reviewed
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[Presentation] Cytoplasmic 5’-nucleotidase 1A are aggregated in type 2 fiber in sporadic inclusion body myositis.2014
Author(s)
Nozomu Tawara, Satoshi Yamashita, Tomo Nishikami, Kensuke Kawakami, Akie Tawara, Hiroko Hori, Tomoo Hirahara, Yasushi Maeda, Yukio Ando.
Organizer
19th International Congress of the World Muscle Society
Place of Presentation
Langenbeck-Virchow-Haus, Berlin, Germany
Year and Date
2014-10-08
Related Report
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