| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In HTLV-1 associated myelopathy (HAM), the infection model that is useful for screening of the medicine does not exist. Therefore, in this study, we tried to establish HTLV-1 infection model and be intended to use it for the screening of therapeutic drugs of HAM. At first, we manufactured a virus reservoir by transducing a virus expression vector to differentiation dendritic cells. Then, we established a rating system of the viral infection to a target cell by making a new index cell. It was confirmed that efficiency of the viral infection decreased by adding a blocking antibody in this system. Because it was thought that HTLV-1 infection model to the T cell via the dendritic cell was established, we will apply this system to the screening of drugs in further study.
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