| Project/Area Number |
24591282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Kaida Kenichi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (40531190)
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| Co-Investigator(Kenkyū-buntansha) |
ONOUE Hiroyuki 防衛医科大学校, その他部局等, 助教 (10392440)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMAKURA Keiko 東京工科大学, 医療保険学部, 教授 (30092183)
KUSUNOKI Susumu 近畿大学, 医学部, 教授 (90195438)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | antibody / neuropathy / ganglioside / ganglioside complex / complement / Guillain-Barre syndrome / 抗ガングリオシド抗体 / 補体活性化能 / IgGサブクラス / neurofascin 155 / ニューロパチー / 自律神経障害 / ガングリオシド複合体 / 補体活性可能 |
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| Outline of Final Research Achievements |
We studied pathogenic roles of anti-glycolipid antibodies in Guillain-Barre; syndrome (GBS), which showed a positive correlation between the antibody activities and complement-activation capacity. Clinical analyses of GBS with autonomic dysfunction revealed that patients with dysautonomia were characterized by cranial nerve deficits, severe disability with frequent artificial ventilation, and electrodiagnostic findings indicative of demyelination. Fluctuating hypertension and vesicorectal disturbance were most frequent autonomic symptoms. Antibodies to neurofascin (NF) 155 were positive in 10% of GBS patients without anti-glycolipid antibodies, although the IgG subclass of anti-NF155 was IgG2. Ten percent of patients with chronic inflammatory demyelinating polyradiculoneuropathy had IgG4 anti-NF155 antibodies, who were featured by younger onset, tremor, prominent high levels of cerebrospinal fluid protein, and negative results of anti-glycolipid antibodies.
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