Research on antiganglioside antibody-associated nerve injury: pathophysiology and novel treatment
| Project/Area Number |
24591282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Kaida Kenichi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (40531190)
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| Co-Investigator(Kenkyū-buntansha) |
ONOUE Hiroyuki 防衛医科大学校, その他部局等, 助教 (10392440)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMAKURA Keiko 東京工科大学, 医療保険学部, 教授 (30092183)
KUSUNOKI Susumu 近畿大学, 医学部, 教授 (90195438)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | antibody / neuropathy / ganglioside / ganglioside complex / complement / Guillain-Barre syndrome / 抗ガングリオシド抗体 / 補体活性化能 / IgGサブクラス / neurofascin 155 / ニューロパチー / 自律神経障害 / ガングリオシド複合体 / 補体活性可能 |
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| Outline of Final Research Achievements |
We studied pathogenic roles of anti-glycolipid antibodies in Guillain-Barre; syndrome (GBS), which showed a positive correlation between the antibody activities and complement-activation capacity. Clinical analyses of GBS with autonomic dysfunction revealed that patients with dysautonomia were characterized by cranial nerve deficits, severe disability with frequent artificial ventilation, and electrodiagnostic findings indicative of demyelination. Fluctuating hypertension and vesicorectal disturbance were most frequent autonomic symptoms. Antibodies to neurofascin (NF) 155 were positive in 10% of GBS patients without anti-glycolipid antibodies, although the IgG subclass of anti-NF155 was IgG2. Ten percent of patients with chronic inflammatory demyelinating polyradiculoneuropathy had IgG4 anti-NF155 antibodies, who were featured by younger onset, tremor, prominent high levels of cerebrospinal fluid protein, and negative results of anti-glycolipid antibodies.
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Report
(5 results)
Research Products
(79 results)
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[Journal Article] Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis.2014
Author(s)
Titulaer MJ, Höftberger R, Iizuka T, Leypoldt F, McCracken L, Cellucci T, Benson LA, Shu H, Irioka T, Hirano M, Singh G, Cobo Calvo A, Kaida K, Morales PS, Wirtz PW, Yamamoto T, Reindl M, Rosenfeld MR, Graus F, Saiz A, Dalmau J.
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Journal Title
Ann Neurol.
Volume: 75
Pages: 411-428
Related Report
Peer Reviewed / Open Access
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[Journal Article] An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barre syndrome with reversible conduction failure.2012
Author(s)
Ogawa, G., Kaida, K., Kuwahara, M., Kimura, F., Kamakura, K. and Kusunoki, S.
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Journal Title
J Neuroimmunol
Volume: 254
Issue: 1-2
Pages: 141-145
DOI
Related Report
Peer Reviewed
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[Presentation] The reactivity of anti‐GM1 antibody to the dimeric GM1: comparison with reactivity to bovine GM1 and its clinical relevance.2015
Author(s)
Keiichi Nakagawa, Kenichi Kaida, Motoi Kuwahara, Susumu Kusunoki, Maria G. Ciampa, Laura Mauri, Sandro Sonnino, Masato Kadoya, Katsunori Ikewaki.
Organizer
Peripheral Nerve Society, Biennial Meeting
Place of Presentation
Quebec, Canada
Year and Date
2015-06-28
Related Report
Int'l Joint Research
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