| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which is characterized by selective motor neuron degeneration in brain and spinal cord. Recently, many genes which function in various cellular events have been identified as ALS-causing genes. To elucidate the common pathomechanisms and therapeutic targets of ALS caused by various genes, we analyzed networks in ALS-causing genes using ALS model flies. In this study, we successfully show that toxicity of TDP-43, an ALS-causing gene, is evoked by dysfunction of microtubule-dependent transport, and revealed that activation of microtubule-dependent transport is a new therapeutic target for AlS.
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