Correlation of Cinicoserologic and Pathologic Features of Inflammatory Myopathies
Project/Area Number |
24591289
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | The University of Tokyo |
Principal Investigator |
SHIMIZU Jun 東京大学, 医学部附属病院, 講師 (40260492)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | inflammatory myopathies / autoantibodies / histology / 筋炎 / 臨床分類 / 筋炎特異自己抗体 / 筋炎関連自己抗体 / 組織 / 統合的アプローチ / 臨床像 / 自己抗体 / 病理像 / 悪性腫瘍 / 網羅的解析 / 抗ミトコンドリア抗体 / 心筋障害 / 呼吸筋障害 |
Outline of Final Research Achievements |
The purpose of the project was to elucidate the correlation among clinical and histological features and autoantibodies in idiopathic inflammatory myopathies (IIMs). I found that patients with IIM associated with anti-mitochondrial antibody frequently have chronic disease course with cardio-pulmonary involvement showing granulomatous inflammation in histopathological findings. I found that patients with serum anti-Tif1γ antibody have close temporal association with cancer and frequently show C5b-9 deposition with perifascicular atrophy as a histological finding. I also found that perifascicular atrophy is a histopathological finding with frequent association with serum anti-Tif1γ, Jo1, or Mi-2 antibodies, which suggested the heterogeneous back ground of dermatomyositis. The above findings suggested that clinic-serological and pathological approach is important not only for classification of IIMs but also for revealing pathological mechanisms of IIMs.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Increased gene dosage of myelin protein zero causes Charcot-Marie-Tooth disease.2012
Author(s)
Maeda MH, Mitsui J, Soong BW, Takahashi Y, Ishiura H, Hayashi S, Shirota Y, Ichikawa Y, Matsumoto H, Arai M, Okamoto T, Miyama S, Shimizu J, Inazawa J, Goto J, Tsuji S
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Journal Title
Ann Neurol
Volume: 71
Pages: 84-92
Related Report
Peer Reviewed
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