| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The purpose of the project was to elucidate the correlation among clinical and histological features and autoantibodies in idiopathic inflammatory myopathies (IIMs). I found that patients with IIM associated with anti-mitochondrial antibody frequently have chronic disease course with cardio-pulmonary involvement showing granulomatous inflammation in histopathological findings. I found that patients with serum anti-Tif1γ antibody have close temporal association with cancer and frequently show C5b-9 deposition with perifascicular atrophy as a histological finding. I also found that perifascicular atrophy is a histopathological finding with frequent association with serum anti-Tif1γ, Jo1, or Mi-2 antibodies, which suggested the heterogeneous back ground of dermatomyositis. The above findings suggested that clinic-serological and pathological approach is important not only for classification of IIMs but also for revealing pathological mechanisms of IIMs.
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