A study of neural connectivity in cortex using a non-invasive physiological technique.

• Project/Area Number: 24591292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: HOSHIYAMA Minoru 名古屋大学, 脳とこころの研究センター, 教授 (30270482)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳磁場 / 体性感覚誘発脳反応 / 皮質内接続 / 脳内神経接続 / 脳磁計 / 誘発脳活動 / MEG / 皮質伝導 / 体性感覚 / 加齢 / 誘発脳磁場 / 視覚誘発脳反応 / 慢性疼痛

Outline of Final Research Achievements

We investigated intra-cortical neural connectivity in human brain using the latest non-invasive magnetoencephalography system (MEG). We focused to clarify distribution of neural signals in somatosensory cortex in young and elderly subjects and patients with central and peripheral neurological disorders. We found that inhibitory neural activity was enhanced in the elderly subjects and patients with peripheral neuropathy than in young subjects.

Research Products

• [Journal Article] Influence of action observation on self-generated performance in schizophrenia. (2015)
  • Author(s): Nakagawa Y, Hoshiyama M.
  • Journal Title: Cogn Neuropsychiat Volume: 0
  • Peer Reviewed
• [Journal Article] Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study (2014)
  • Author(s): Goto, S. Fujisawa, Y. Uemura, J. I. Yamada, S. Hoshiyama, M. Hirayama, M
  • Journal Title: Clin Neurophysiol Volume: 126 Issue: 6 Pages: 1228-33
  • DOI: 10.1016/j.clinph.2014.09.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of environmental stimulation on recognition of mealtimes in patients with dementia. (2014)
  • Author(s): Tanaka M, Hoshiyama M.
  • Journal Title: Phys Occup Ther Geriat Volume: 32 Issue: 2 Pages: 112-122
  • DOI: 10.3109/02703181.2014.890266
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Behavioral and physiological observation during the daytime: How patients with advanced dementia spend the time in a care facility. (2014)
  • Author(s): Yamaguchi K, Hoshiyama M.
  • Journal Title: Asian J Occup Ther Volume: 10 Pages: 17-14
  • Peer Reviewed
• [Journal Article] Compensatory postural sway while seated posture during tasks in children with autism spectrum disorder. (2014)
  • Author(s): Funahashi Y, Karashima C, Hoshiyama M.
  • Journal Title: Occup Ther Int Volume: 21 Issue: 4 Pages: 166-175
  • DOI: 10.1002/oti.1375
  • Peer Reviewed
• [Journal Article] Effects of environmental stimulation on recognition of mealtimes in patients with dementia (2014)
  • Author(s): Tanaka M, Hoshiyama M
  • Journal Title: Phys Occup Ther Geriat Volume: in press
  • Peer Reviewed
• [Journal Article] Behavioral and physiological observation during the daytime: How patients with advanced dementia spend the time in a care facility (2014)
  • Author(s): Yamaguchi K, Hoshiyama M
  • Journal Title: Asian J Occup Ther Volume: in press
  • Peer Reviewed
• [Journal Article] Effects of emotional music on visual processes in inferior temporal area (2013)
  • Author(s): Jomori I, Hoshiyama M, Uemura J, Nakagawa Y, Hoshino A, Iwamoto Y
  • Journal Title: Cognitive Neuroscience Volume: 4 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Effects of emotional music on visual processes in inferior temporal area. (2013)
  • Author(s): Jomori I, Hoshiyama M, Uemura J, Nakagawa Y, Hoshino A, Iwamoto Y.
  • Journal Title: Cognitive Neuroscience Volume: 4 Issue: 1 Pages: 21-30
  • DOI: 10.1080/17588928.2012.751366
  • Peer Reviewed
• [Journal Article] Auditory MEG mismatch responses modified by visual stimulation accompanying auditory stimulation (2012)
  • Author(s): Nakagawa Y, Hoshiyama M, Uemura J, Jomori I.
  • Journal Title: Neurophysiology Volume: 44 Issue: 3 Pages: 247-254
  • DOI: 10.1007/s11062-012-9294-9
  • Peer Reviewed
• [Journal Article] Time orientation during the day in the elderly with dementia. (2012)
  • Author(s): Iwamoto Y, Hoshiyama M.
  • Journal Title: Physical & Occupational Therapy in Geriatrics Volume: 30 Issue: 3 Pages: 202-213
  • DOI: 10.3109/02703181.2012.713453
  • Peer Reviewed
• [Journal Article] Virbroarthrography in patients with knee arthropathy. (2012)
  • Author(s): Tanaka N, Hoshiyama M.
  • Journal Title: Journal of Back & Musculoskeletal Rehabilitation Volume: 25 Issue: 2 Pages: 117-122
  • DOI: 10.3233/bmr-2012-0319
  • Peer Reviewed
• [Journal Article] Articular sound and clinical stages in knee arthropathy. (2012)
  • Author(s): Tanaka N, Hoshiyama M.
  • Journal Title: Journal of Musculoskeletal Research Volume: 14 Pages: 1-9
  • Peer Reviewed
• [Presentation] 脳磁図を用いた手根管症候群における脳皮質の変化の検証． (2015)
  • Author(s): 岩月克之，平田仁，寳珠山稔，上村純一，平山正昭．
  • Organizer: 第58回日本手外科学会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-16 – 2015-04-17
• [Presentation] Visual evoked response in the primary visual cortex in Parkinson’s disease and aging effects: a magneto-encephalogarphic study (2013)
  • Author(s): Goto S. Hirayama M, Hoshiyama M.
  • Organizer: 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: シドニー、豪州
• [Presentation] 脳磁図を用いた若年者と高齢者における連続痛覚刺激に対する抑制反応 (2013)
  • Author(s): 後藤沙絵、平山正昭、寳珠山稔
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知市
• [Remarks] 脳とこころの研究センター
  • URL: http://www.med.nagoya-u.ac.jp/noutokokoro/