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Efficacy of cholinesterase inhibitor drugs in early Parkinson's disease patients

Research Project

Project/Area Number 24591293
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

WATANABE hirohisa  名古屋大学, 脳とこころの研究センター, 特任教授 (10378177)

Co-Investigator(Kenkyū-buntansha) ITO Mizuki  名古屋大学, 医学部附属病院, 助教 (50437042)
SENDA Joe  名古屋大学, 医学部附属病院, 医員 (80569781)
NAKAMURA Tomohiko  名古屋大学, 医学部附属病院, 助教 (00437039)
HIRAYAMA Masaaki  名古屋大学, 医学系研究科, 准教授 (30283435)
SOBUE Gen  名古屋大学, 医学系研究科, 教授 (20148315)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsパーキンソン病 / 精神症状 / 神経画像 / MRI / 神経放射線 / 認知症 / 早期診断 / 幻覚 / 脳内神経回路 / 予防 / 抗コリンエステラーゼ阻害剤 / 認知機能 / functional MRI / magnetoencephalography
Outline of Final Research Achievements

In Parkinson's disease with visual hallucination (The PD-VH) patients, they showed significant cortical atrophy compared to the PD patients without visual hallucination in the frontal lobe (bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex), occipital and parietal cortex (bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus). Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus. Visual hallucination in PD can occur due to distinctive neuroanatomical involvement. We also demonstrated that patients with severe olfactory dysfunction showed significant involvement of amygdala, substantia nigra, and insular network.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Voice features of Parkinson's disease patients with subthalamic nucleus deep brain stimulation.2015

    • Author(s)
      Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Fujimoto Y, Ohdake R, Yoneyama N, Masuda M, Hara K, Senda J, Ito M, Atsuta N, Horiguchi S, Yamamoto M, Wakabayashi T, Sobue G.
    • Journal Title

      J Neurol

      Volume: Epub

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function.2015

    • Author(s)
      Maesawa S, Bagarinao E, Fujii M, Futamura M, Motomura K, Watanabe H, Mori D, Sobue G, Wakabayashi T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0118072-e0118072

    • DOI

      10.1371/journal.pone.0118072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation.2014

    • Author(s)
      Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Nakamura R, Watanabe H, Senda J, Atsuta N, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: Epub Issue: 8 Pages: 856-64

    • DOI

      10.1136/jnnp-2014-308043

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease2014

    • Author(s)
      Mizutani, Y. Nakamura, T. Okada, A. Suzuki, J. Watanabe, H. Hirayama, M. Sobue, G.
    • Journal Title

      Parkinsonism & related disorders

      Volume: 20 Issue: 5 Pages: 520-4

    • DOI

      10.1016/j.parkreldis.2014.02.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease2014

    • Author(s)
      Nakamura, T. Hirayama, M. Hara, T. Mizutani, Y. Suzuki, J. Watanabe, H. Sobue, G.
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 20 Issue: 4 Pages: 409-14

    • DOI

      10.1016/j.parkreldis.2014.01.003

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination2013

    • Author(s)
      Watanabe, H. Senda, J. Kato, S. Ito, M. Atsuta, N. Hara, K. Tsuboi, T. Katsuno, M. Nakamura, T. Hirayama, M. Adachi, H. Naganawa, S. Sobue, G.
    • Journal Title

      Mov Disord

      Volume: 28 Issue: 12 Pages: 1732-6

    • DOI

      10.1002/mds.25641

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired pain processing in Parkinson's disease and its relative association with the sense of smell2013

    • Author(s)
      Hara, T. Hirayama, M. Mizutani, Y. Hama, T. Hori, N. Nakamura, T. Kato, S. Watanabe, H. Sobue, G.
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 19 Issue: 1 Pages: 43-6

    • DOI

      10.1016/j.parkreldis.2012.06.020

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis.2012

    • Author(s)
      Senda Joe
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 319 Issue: 1-2 Pages: 105-110

    • DOI

      10.1016/j.jns.2012.04.019

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Widespread cortical and subcortical brain atrophy in Parkinson's disease with excessive daytime sleepiness2012

    • Author(s)
      Kato S, et al
    • Journal Title

      Journal of Neurology

      Volume: 259 Issue: 2 Pages: 318-326

    • DOI

      10.1007/s00415-011-6187-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Cortical and subcortical brain atrophy in Parkinson’s disease with visual hallucination.2013

    • Author(s)
      H. Watanabe, J. Senda, S. Kato, M. Ito, N. Atsuta, K. Hara, T. Tsuboi, M. Katsuno, T. Nakamura, M. Hirayama, S. Naganawa, G. Sobue.
    • Organizer
      17th International Congress of Parkinson’s Disease and Movement Disorders
    • Place of Presentation
      Australia,Sydney
    • Related Report
      2013 Research-status Report
  • [Presentation] 幻視を呈するパーキンソン病におけるvoxel based morphometry所見2012

    • Author(s)
      渡辺 宏久, 千田 譲, 加藤 重典, 伊藤 瑞規, 熱田 直樹, 渡辺 はづき, 原 一洋, 坪井 崇, 中村 亮一, 長縄 慎二, 祖父江 元
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Book] PROGRESS IN MEDICINE2012

    • Author(s)
      渡辺宏久, 加藤重典, 千田譲, 伊藤瑞規, 祖父江元
    • Publisher
      ライフ・サイエンス
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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