| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We previously found that injured mitochondria in motoneurons occur neuroaxonal dystrophy in PLA2G6 knockout mice, which is an excellent model of familial parkinsondisease (PARK14).In this research, we demonstrated neuroaxonal dystrophy occurs also in dopaminergic neurons of PLA2G6 knockout mice. More, endogenous alpha-synuclein accumulated to injured mitochondria of motoneurons in PLA2G6 knockout mice. In patient’s brain, lewy bodies contained much component of mitochondrial membranes. These suggests that the mitochondrial membranes would be associated with alpha-synucleinopathy.
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