The impact of dyslipidemia on the prognosis and the recurrence in the patients with ischemic stroke
| Project/Area Number |
24591300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAZONO Takanari 九州大学, 医学研究院, 教授 (70284487)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMOUCHI Masahiro 九州大学, 医学研究院, 教授 (80346783)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳梗塞 / 予後 / 再発 / 脂質異常症 / HDLコレステロール / スタチン / アディポネクチン / 脳神経疾患 / 病型 |
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| Outline of Final Research Achievements |
We investigated the prognosis of stroke patients from Fukuoka Stroke Registry (FSR) database. On February 28, 2015, the FSR data had the registration of 10,388 cases. In the consecutive ischemic stroke patients, we showed prescribed doses of statins reduced the risks of cerebrovascular events and all-cause mortality in a cohort of Japanese patients with first-ever ischemic stroke. Also, in stroke patients with diabetes mellitus, age, NIHSS score on admission, diabetic nephropathy and HbA1c were independently associated with a poor outcome 1 year after the first ischemic stroke. Furthermore, it was found that in patients with cardioembolic ischemic stroke age and C reactive protein were independent risk factors for recurrence in the first year after onset, and plasma adiponectin values might help to classify stroke subtypes and predict neurological severity and functional outcome in ischemic stroke patients.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS).2014
Author(s)
Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.
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Journal Title
Metabolism
Volume: 63
Pages: 1093-1103
Related Report
Peer Reviewed
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[Journal Article] High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry.2014
Author(s)
Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators.
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Journal Title
Hypertension
Volume: 63
Pages: 54-60
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study.2013
Author(s)
Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.
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Peer Reviewed
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[Presentation] The impact of estimated glomerular filtration rate on a recurrence of ischemic stroke: the Fukuoka Stroke Registry2014
Author(s)
Takahiro Kuwashiro, Masahiro Kamouchi, Yasuhiko Kumai, Koichiro Maeda, Takeshi Uwatoko, Yoshiyuki Wakugawa, Tetsuro Ago, Masahiro Yasaka, Yasushi Okada, Takanari Kitazono
Organizer
International Stroke Conference 2014
Place of Presentation
San Diego, U.S.A.
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