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Application of transcranial magnetic stimulation to elucidate the association of human speech and motor function

Research Project

Project/Area Number 24591301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKagoshima University

Principal Investigator

TOKIMURA Hiroshi  鹿児島大学, 医歯(薬)学総合研究科, 准教授 (50227568)

Co-Investigator(Kenkyū-buntansha) YUNOKUCHI Kazutomo  鹿児島大学, 理工学研究科, 教授 (10094187)
HANAYA Ryosuke  鹿児島大学, 医学部・歯学部附属病院, 講師 (60304424)
ETOH Seiji  鹿児島大学, 医学部・歯学部附属病院, 講師 (70295244)
ARITA Kazunori  鹿児島大学, 医歯(薬)学総合研究科, 教授 (90212646)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords磁気刺激 / 言語機能 / 大脳半球優位性 / 失語症 / 片麻痺 / 運動誘発電位 / 一時運動野 / 一次運動野 / 言語中枢 / 顔面運動 / 顔面神経 / 開頭術
Outline of Final Research Achievements

We investigate the effects of speech on the excitability of corticospinal pathways to human hand muscles. Herewith, we established a new method to identify the human cerebral hemispheric dominancy. In left handers, hemispheric dominancy is in left side or bilateral side, which was influenced by the subjects’ handedness switch in their childhood.
The patients with neurosurgical disease in their cerebral hemisphere needs to evaluate their hemispheric dominancy preoperatively, therefore, we applied our method to these patients. The results obtained from the patients revealed good correlation between the results by our method and those of Amytal test. Our new method is useful to determine human hemispheric dominancy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (13 results)

  • [Journal Article] Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgery2014

    • Author(s)
      Hiroshi Tokimura, Sei Sugata, Hitoshi Yamahata, Shunji Yunoue, Ryosuke Hanaya, Kazunori Arita
    • Journal Title

      Neurosurgical Review

      Volume: 37 Issue: 4 Pages: 669-676

    • DOI

      10.1007/s10143-014-0561-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of the pterional keyhole approach for the treatment of anterior circulation aneurysms2014

    • Author(s)
      Hitoshi Yamahata, Hiroshi Tokimura, Kenichiro Tajitsu, Masahiro Tsuchiya, Ayumi Taniguchi, Masashi Hirabaru, Kenji Takayama, Tomomi Shinsato, Takahisa Hirayama,Kazunori Arita
    • Journal Title

      Neurosurgical Review

      Volume: 37 Issue: 4 Pages: 329-636

    • DOI

      10.1007/s10143-014-0562-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological Mapping of the Temporal Branch of the Facial Nerve.2013

    • Author(s)
      Tokimura H, Hirabaru M, Miyajima S, Tajitsu K, Yamahata H, Sugata S, Arita K.
    • Journal Title

      Journal of neurological surgery. Part A, Central European neurosurgery.

      Volume: 75 Issue: 02 Pages: 116-119

    • DOI

      10.1055/s-0033-1343981

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Are there excitability changes in the hand motor cortex during speech in left-handed subjects?2012

    • Author(s)
      Hiroshi Tokimura, Yoshika Tokimura, Kazunori Arita
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 3 Pages: 148-153

    • NAID

      10030127597

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 前方循環脳動脈瘤クリッピングにおけるpterional keyholeアプローチの有用性2015

    • Author(s)
      時村洋、山畑仁志、田実謙一郎、土屋政寛、谷口歩、平原正志、川野弘人、平山貴久、菅田真生、有田和徳
    • Organizer
      日本脳卒中の外科学会
    • Place of Presentation
      広島市(NTTクレドホール、メルパルク広島、リーガロイヤルホテル広島、広島グリーンアリーナ)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgery2014

    • Author(s)
      Hiroshi Tokimura, Sei Sugata, Hitoshi Yamahata, Shunji Yunoue, Kazunori Arita
    • Organizer
      15th European Congress of Neurosurgery
    • Place of Presentation
      Prague(チェコ)
    • Year and Date
      2014-10-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 聴神経腫瘍手術における持続facial motor evoked potential(fMEP)2014

    • Author(s)
      時村 洋、菅田 真生、山畑 仁志、田実 謙一郎、花谷亮典、平野宏文、有田 和徳
    • Organizer
      日本脳腫瘍の外科学会
    • Place of Presentation
      東京都(東京ドームホテル)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgery2013

    • Author(s)
      Hiroshi Tokimura, Sei Sugata, Hitoshi Yamahata, Kazunori Arita
    • Organizer
      Joint Neurosurgical Convention 2013 (The 6th Mt. Bandai Symposium for Neuroscience and the 7th Pan-Pacific Neurosurgery Congress)
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Transcranial Magnetic Stimulation 言語への適用2013

    • Author(s)
      Hiroshi Tokimura
    • Organizer
      Padjadjaran University、Special seminar
    • Place of Presentation
      Bandung, Indonesia
    • Related Report
      2013 Research-status Report
  • [Presentation] Transcranial Magnetic Stimulation 言語への適用2013

    • Author(s)
      時村 洋
    • Organizer
      第25回臨床神経生理研究会
    • Place of Presentation
      福岡リーセントホテル, 福岡市, 福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 聴神経腫瘍手術における 持続facial motor evoked potential(fMEP)2013

    • Author(s)
      時村 洋、菅田 真生、山畑 仁志、田実 謙一郎、花谷亮典、平野宏文、有田 和徳
    • Organizer
      第18回日本脳腫瘍の外科学会
    • Place of Presentation
      大津プリンスホテル, 大津市, 滋賀
    • Related Report
      2013 Research-status Report
  • [Presentation] Transcranial Magnetic Stimulation-言語への適用-2013

    • Author(s)
      時村 洋
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化センター, 高知市, 高知
    • Related Report
      2013 Research-status Report
  • [Presentation] Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgery2013

    • Author(s)
      Hiroshi Tokimura, Sei Sugata, Hitoshi Yamahata, Kazunori Arita
    • Organizer
      Joint Neurosurgical Convention 2013
    • Place of Presentation
      Hawaii
    • Related Report
      2012 Research-status Report
  • [Presentation] Transcranial Magnetic Stimulation 言語への適用2012

    • Author(s)
      時村 洋
    • Organizer
      関東機能的脳外科カンファレンス
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 聴神経腫瘍摘出術における持続MEPモニタリング2012

    • Author(s)
      時村 洋、菅田真生、山畑仁、有田和徳
    • Organizer
      日本臨床神経生理学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 聴神経腫瘍手術における持続facial motor evoked potentialの有用性2012

    • Author(s)
      時村 洋、菅田真生、山畑仁志、田実謙一郎、花谷亮典、平野宏文、有田和徳
    • Organizer
      日本脳腫瘍の外科学会:シンポジウム5術中脳神経モニタリングの検証
    • Place of Presentation
      神奈川
    • Related Report
      2012 Research-status Report
  • [Presentation] Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgery2012

    • Author(s)
      Hiroshi Tokimura, Sei Sugata, Hitoshi Yamahata, Ryosuke Hanaya, Hirofumi Hirano, Kazunori Arita
    • Organizer
      日独合同脳神経外科会議
    • Place of Presentation
      ドイツ
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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