Application of functional connectivity measured with resting state fMRI to epilepsy treatment
| Project/Area Number |
24591303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DONISHI Tomohiro 和歌山県立医科大学, 医学部, 助教 (70326354)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | てんかん / 機能的結合 / 機能的MRI / 診断 / ｆMRI / 臨床応用 / 治療 / 脳機能 |
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| Outline of Final Research Achievements |
We investigated the resting state functional MRI data for more than 30 patients with various types of epilepsy (most cases were medically intractable patients). These data were compared with more than 300 normal controls’ data. We found that the patients with epilepsy tended to have larger functional connectivity than age-matched controls, especially around the epileptic focus estimated by electroencephalography. Brain functional network was stable when the patient’s symptom and medication did not change. After the surgery to resect epileptic focus, the patient’s brain network changed dramatically toward normal network. The results indicates that the brain network analysis in epilepsy is useful in diagnosis and treatment planning for the various types of epilepsy patients.
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Report
(4 results)
Research Products
(9 results)
