| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The goal of this study is to establish the biomarker of PD by comparing the BGTM connectivity between control, PD and Atypical Parkinsonism (AP). PD patients, AP patients and age-matched control subjects performed a protocol involving finger movements, while being scanned with functional magnetic resonance imaging. Analysis using structural equation modeling (SEM) exhibited reduced connectivity from the thalamus to the motor cortices in AP and PD patients compared with control group, while there was disturbed connectivity within the lentiform nucleus only in the AP group. These results suggest the utility of SEM for biomarker of PD.
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