Hypertensive neuropathy: underlying mechanisms
| Project/Area Number |
24591307
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | The Nukada Institute for Medical and Biological Reseach |
|---|
Principal Investigator |
NUKADA Hitoshi 公益財団法人額田医学生物学研究所, その他部局等, 理事長 (60118833)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAGIHASHI Soroku 弘前大学, 医学部, 特任教授 (40111231)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
BABA Masayuki 青森県立中央病院, 神経内科, 部長 (90106849)
NARUSE Keiko 愛知学院大学, 医学部, 助教授 (30387576)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 末梢神経障害 / 高血圧 / 糖尿病 / 細小血管障害 / 末梢神経病理 / SHR / 高血圧臓器障害 / 糖尿病合併症 / 神経伝導速度 / 細小血管症 |
|---|
| Outline of Final Research Achievements |
Hypertension has been reported to cause neuropathic processes clinically and experimentally. In addition, hypertension is a major correlate for the development and progression of diabetic polyneuropathy. There is evidence that if hypertension is inadequately treated in diabetic patients, then the rate of progression of neuropathy is greater than in those patients with good blood pressure control.
We have demonstrated that the electrophysiological and morphological abnormalities in sciatic-tibial and sural nerves of spontaneously hypertensive rats (SHR). SHR exhibited nerve microangiopathy as seen in human diabetic neuropathy. These microvascular changes became evident when nerve conduction velocity was delayed. We suggest that sustained severe hypertension could induce neuropathic processes associated with nerve microangiopathy. Hypertension causes nerve microangiopathy and may play an important role in the development of microangiopathy in human diabetic neuropathy.
|
Report
(4 results)
Research Products
(42 results)
-
-
[Journal Article] Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).2014
Author(s)
Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Fernyhough P, Malik RA, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW
-
Journal Title
J Peripher Nerv Syst
Volume: 19
Pages: 77-87
Related Report
Peer Reviewed
-
[Journal Article] Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.2014
Author(s)
Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y.
-
Journal Title
Biochem Biophys Res Commun
Volume: 443
Pages: 1014-1020
Related Report
Peer Reviewed
-
[Journal Article] Therapeutic effect of exendin-4, a long-acting analogue of glucagon-like peptide-1 receptor agonist, on nerve regeneration after the crush nerve injury.2013
Author(s)
Yamamoto K, Amako M, Yamamoto Y, Tsuchihara T, Nukada H, Yoshihara Y, Arino H, Fujita M, Uenoyama M, Tachuibana S, Nemoto K.
-
Journal Title
Bio Med Research International
Volume: 10
Pages: 1155-1162
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cells.2013
Author(s)
Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H.
-
Journal Title
Endocrinology
Volume: 154
Pages: 4512-4524
Related Report
Peer Reviewed
-
[Journal Article] Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.2013
Author(s)
Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y.
-
Journal Title
Biochem Biophys Res Commun
Volume: 436
Pages: 698-704
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
