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Hypertensive neuropathy: underlying mechanisms

Research Project

Project/Area Number 24591307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionThe Nukada Institute for Medical and Biological Reseach

Principal Investigator

NUKADA Hitoshi  公益財団法人額田医学生物学研究所, その他部局等, 理事長 (60118833)

Co-Investigator(Kenkyū-buntansha) YAGIHASHI Soroku  弘前大学, 医学部, 特任教授 (40111231)
Co-Investigator(Renkei-kenkyūsha) BABA Masayuki  青森県立中央病院, 神経内科, 部長 (90106849)
NARUSE Keiko  愛知学院大学, 医学部, 助教授 (30387576)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords末梢神経障害 / 高血圧 / 糖尿病 / 細小血管障害 / 末梢神経病理 / SHR / 高血圧臓器障害 / 糖尿病合併症 / 神経伝導速度 / 細小血管症
Outline of Final Research Achievements

Hypertension has been reported to cause neuropathic processes clinically and experimentally. In addition, hypertension is a major correlate for the development and progression of diabetic polyneuropathy. There is evidence that if hypertension is inadequately treated in diabetic patients, then the rate of progression of neuropathy is greater than in those patients with good blood pressure control.
We have demonstrated that the electrophysiological and morphological abnormalities in sciatic-tibial and sural nerves of spontaneously hypertensive rats (SHR). SHR exhibited nerve microangiopathy as seen in human diabetic neuropathy. These microvascular changes became evident when nerve conduction velocity was delayed. We suggest that sustained severe hypertension could induce neuropathic processes associated with nerve microangiopathy. Hypertension causes nerve microangiopathy and may play an important role in the development of microangiopathy in human diabetic neuropathy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (42 results)

All 2015 2014 2013 2012 Other

All Journal Article (17 results) (of which Peer Reviewed: 13 results) Presentation (21 results) (of which Invited: 5 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Impaired nerve fiber re- generation in axotomized peripheral nerves in streptozotocin-diabetic rats.2014

    • Author(s)
      Nishida N, Yamagishi S, Mizukami H, Yagihashi S
    • Journal Title

      J Diabetes Invest

      Volume: 4 Pages: 533-539

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).2014

    • Author(s)
      Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Fernyhough P, Malik RA, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW
    • Journal Title

      J Peripher Nerv Syst

      Volume: 19 Pages: 77-87

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.2014

    • Author(s)
      Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Pages: 1014-1020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of exendin-4, a long-acting analogue of glucagon-like peptide-1 receptor agonist, on nerve regeneration after the crush nerve injury.2013

    • Author(s)
      Yamamoto K, Amako M, Yamamoto Y, Tsuchihara T, Nukada H, Yoshihara Y, Arino H, Fujita M, Uenoyama M, Tachuibana S, Nemoto K.
    • Journal Title

      Bio Med Research International

      Volume: 10 Pages: 1155-1162

    • DOI

      10.1155/2013/315848

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高齢者における自立度別病態像と栄養状態の研究2013

    • Author(s)
      松本 光、伊藤香奈、内田菜穂子、高木亜由美、高橋美千代、金子健彦、額田 均、古橋紀久、橋詰直孝
    • Journal Title

      New Diet Therapy

      Volume: 29 Pages: 3-19

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cells.2013

    • Author(s)
      Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H.
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 4512-4524

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.2013

    • Author(s)
      Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 436 Pages: 698-704

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disseminated infection and pulmonary embolization of Cunninghamella bertholletiae complicated with hemophagocytic lymphohistiocytosis.2013

    • Author(s)
      Hirayama Y, Yajima N, Kaimori M, Akagi T, Kubo K, Saito D, Hizawa Y, Wada R, Yagihashi S.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 2275-2279

    • NAID

      130003392582

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.2013

    • Author(s)
      Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S.
    • Journal Title

      Pancreas

      Volume: 42 Pages: 786-794

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa.2013

    • Author(s)
      Yajima N, Wada R, Kimura S, Matsuzaki Y, Chiba D, Ebina Y, Ohkusu K, Yagihashi S.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 219-222

    • NAID

      130003365854

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats.2013

    • Author(s)
      Sugimoto K, Baba M, Suzuki S, Yagihashi S.
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Primary gastric synovial sarcoma: molecular diagnosis and prediction of prognosis.2013

    • Author(s)
      Kamata K, Wada R, Yajima N, Sawada M, Wakasa H, Yagihashi S.
    • Journal Title

      Clin J Gastroenterol

      Volume: 6 Pages: 303-308

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 糖尿病性神経障害の成因研究の進歩2013

    • Author(s)
      八木橋操六、水上 浩哉
    • Journal Title

      医学のあゆみ

      Volume: 44 Pages: 139-145

    • Related Report
      2013 Research-status Report
  • [Journal Article] 糖尿病性多発神経障害の成因を考える : 病理と生化学の関連 (特集 糖尿病性神経障害臨床のピットフォール : 糖尿病および関連領域専門医それぞれの立場から) 。2013

    • Author(s)
      水上 浩哉 , 八木橋操六
    • Journal Title

      糖尿病

      Volume: 5 Pages: 6-13

    • NAID

      40019808899

    • Related Report
      2013 Research-status Report
  • [Journal Article] 糖尿病神経障害の成因-血流障害2013

    • Author(s)
      額田 均
    • Journal Title

      糖尿病臨床のすべて 糖尿病性神経障害:基礎から臨床のすべて

      Volume: 1 Pages: 96-101

    • Related Report
      2012 Research-status Report
  • [Journal Article] 糖尿病性神経障害の成因-血管性因子2012

    • Author(s)
      額田 均
    • Journal Title

      月刊糖尿病 特集「糖尿病と神経障害」

      Volume: 3 Pages: 33-40

    • Related Report
      2012 Research-status Report
  • [Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve2012

    • Author(s)
      Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
    • Journal Title

      Brain Res

      Volume: 1373 Pages: 172-182

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 末梢神経と虚血、シンポジウム「末梢神経障害」2015

    • Author(s)
      額田 均
    • Organizer
      第58回日本手外科学会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 特発性後骨間神経麻痺における“くびれ”の病理像2015

    • Author(s)
      小松雅俊、額田 均、内山茂晴、山崎 宏、加藤博之
    • Organizer
      第58回日本手外科学会、2015.4.17
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hypertensive neuropathy in spontaneously hypertensive rat2014

    • Author(s)
      Nukada H, Baba M, McMorran D, Yagihashi S
    • Organizer
      32nd World Congress of Internal Medicine
    • Place of Presentation
      韓国・ソウル
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病治療薬エキセンディン―4 の神経損傷に対する有効性2014

    • Author(s)
      山元 浩治、尼子 雅敏、中谷 創、土原 豊一、額田 均、有野 浩司、吉原 愛雄、山本 頼綱、上野山 真紀、立花 正一、根本 孝一
    • Organizer
      第29回日本整形外科基礎学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病治療薬エキセンディン―4 の末梢神経損傷に対する用量依存効果2014

    • Author(s)
      山元 浩治、尼子 雅敏、中谷 創、土原 豊一、額田 均、有野 浩司、吉原 愛雄、山本 頼綱、上野山 真紀、立花 正一、根本 孝一
    • Organizer
      第29回日本整形外科基礎学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特発性後骨間神経麻痺における“くびれ”の病理像2014

    • Author(s)
      小松雅俊、山崎 宏、林 正徳、植村一貴、内山茂晴、池田修一、額田 均、加藤博之
    • Organizer
      第25回日本末梢神経学会
    • Place of Presentation
      京都
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病性末梢神経障害に対する高血圧の影響:高血圧自然発症ラット(SHR)での検討2014

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病性末梢神経障害に対する高血圧の影響:高血圧自然発症ラット(SHR)での検討2014

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第55回日本神経学会
    • Place of Presentation
      博多
    • Year and Date
      2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高血圧性末梢神経障害での細小血管症

    • Author(s)
      額田 均、 馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 高血圧性末梢神経障害での細小血管症

    • Author(s)
      額田 均、 馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] SHR末梢神経の細小血管症

    • Author(s)
      額田 均、 馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第36回日本高血圧学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Cold injury to peripheral nerve

    • Author(s)
      Nukada H, Pollock M
    • Organizer
      “Cryomedicine 2013”,The 40th Annual Meeting of Japan Society for Low Temperature Medicine
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 糖尿病性神経障害の新しい展開

    • Author(s)
      八木橋操六
    • Organizer
      第56回日本糖尿病学会学術集会シンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 糖尿病病理学の進歩。形態と機能の相関を求めて(宿題報告)

    • Author(s)
      八木橋操六
    • Organizer
      第101回日本病理学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 高血圧性末梢神経障害:SHRでの検討

    • Author(s)
      額田 均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
    • Organizer
      第53回日本神経学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 高血圧性末梢神経障害:SHRでの検討

    • Author(s)
      額田 均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
    • Organizer
      第55回日本糖尿病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Microangiopathy in hypertensive neuropathy

    • Author(s)
      Nukada H, Baba M, Ogasawara S, McMorran D, Mizukami H, Yagihashi S
    • Organizer
      2012 NEURODIAB Meeting
    • Place of Presentation
      ドレスデン、ドイツ
    • Related Report
      2012 Research-status Report
  • [Presentation] Vascular factors in diabetic neuropathy with special reference to the impact of hypertension

    • Author(s)
      Nukada H
    • Organizer
      9th Congress of International Diabetes Federation Western Pacific Region, and 4th Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 高血圧性末梢神経障害での細小血管症

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第56回日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] 高血圧性末梢神経障害における細小血管症

    • Author(s)
      額田 均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 高齢者における糖尿病性閉塞性動脈硬化症の症例

    • Author(s)
      額田 均
    • Organizer
      第4回千葉市糖尿病と合併症・関連疾患を考える会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Book] Ischemia and diabetic neuropathy. In: Handbook of Clinical Neurology: Diabetes and the Nervous System. Malik R, Zochodne D (eds)2014

    • Author(s)
      Nukada H
    • Publisher
      Elsevier, Edinburgh
    • Related Report
      2014 Annual Research Report
  • [Book] 糖尿病神経障害の成因-血流障害、糖尿病臨床のすべて:糖尿病性神経障害、基礎から臨床のすべて。荒木栄一、中村二郎(編)2013

    • Author(s)
      額田 均
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Remarks] 公益財団法人 額田医学生物学研究所

    • Related Report
      2013 Research-status Report
  • [Remarks] 公益財団法人 額田医学生物学研究所

    • URL

      http://www.nukada.or.jp/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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