| Project/Area Number |
24591316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center (2013-2014)
The University of Tokyo (2012) |
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Principal Investigator |
KAMEI Nozomu 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 (00448242)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Ryo 東京大学, 医学部附属病院, 講師 (20396732)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | インスリン抵抗性 / 糖尿病 / 脂肪組織 / 炎症 / 好中球 |
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| Outline of Final Research Achievements |
Obesity and type 2 diabetes are now considered systemic immunological diseases. Many types of immune cells, such as T cells, B cells, NK cells or Eosinophils, in adipose tissues may play a crucial role in the development of obesity-induced insulin resistance by affecting the infiltration and activation of adipose tissue macrophages. Neutrophils may also have an important role in obesity-induced adipose tissue inflammation and systemic insulin resistance.
We found that the neutrophil number in mouse adipose tissue was increased by the refed stimulation after fasted, which meant these cells infiltrated into fat in dynamic way. The adipose tissue neutrophils showed specific character compare to spleen neutrophils by the RNA sequencing method. The adipose tissue neutrophils from obese mice were different in their character from those from lean mice.
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