| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Entrainment of daily rhythms in biological clock, sleep/wake, and metabolism is required for maintaining glucose homeostasis. The present study was conducted to elucidate how these different rhythmic systems are coordinated in mice. The observed results demonstrated that hypothalamic orexin system bidirectionally regulated hepatic gluconeogenesis, thereby generating daily rhythm of blood glucose levels according to the circadian clock rhythm and sleep/wake cycles. The daily glucose oscillation contributed not only to supply of energy at the awake period but also to reduction of blood glucose levels during the sleep period, thereby preventing insulin resistance. Administration of orexin at awake but not sleep period improved hyperglycemia in type 2 diabetic mice. Thus, hypothalamic orexin system is considered to be a novel chronotherapeutic target for type 2 diabetes.
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