| Project/Area Number |
24591326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kagoshima University (2013-2014)
Kyoto University (2012) |
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Principal Investigator |
KATSUURA Goro 鹿児島大学, 医歯(薬)学総合研究科, 特任講師 (20401226)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Nobuko 慶応大学, 医学部, 助教 (50400891)
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| Co-Investigator(Renkei-kenkyūsha) |
MANABE Toshiya 東京大学, 医科学研究所, 教授 (70251212)
AKAIKE Akinori 京都大学, 大学院・薬学研究科, 教授 (80135558)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 過食 / 肥満 / 報酬系 / 視床下部 / オピエート / 摂食調節 / 中脳辺縁系 / 食事性肥満モデルマウス / 絶食‐再摂食 |
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| Outline of Final Research Achievements |
Food intake is considered to be controlled by the mesolimbic dopamine system(the reward system) as well as the hypothalamus. In this study, we observed the effects of high-fat diet on the food intake regulating factors in the hypothalamus and reward regulating factors in the nucleus accumbence in mice fed on control diet and high-fat diet follwing fasting and refeeding.Moreover, the effects of opiate receptor antagonists on refeeding in both groups of mice were examined. The expressions of the food intake regulating factors and the reward regulating factors in the mice fed on high-fat diet were siginicantly different from those in the mice fed on control diet. Moreover, the responses to opiate receptor antagonist in refeeding of the mice fed on high-fat diet were markedly different from those in the mice fed on control diet. These results indicate that feeding of high-fat diet may influence the mesolimbic dopamin system (the reward system) as well as the hypothalamus.
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