Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Outline of Final Research Achievements |
It is well known that pancreatic transcription factor PDX-1 plays a crucial role in maintenance of pancreatic beta-cell function but that its expression level is decreased under diabetic conditions. We made beta-cell-specific PDX-1 overexpressing transgenic mice. As the results, such PDX-1 overexpresion ameliorated glycemic control in diabetic Akita mice. It is also known that incretins (GLP-1 and GIP) play a crucial role in maintenance of beta-cell function but that GLP-1 and GIP receptor levels are decreased. We made beta-cell-specific GLP-1 receptor overexpressing transgenic mice. As the results, such GLP-1 receptor overexpresion augmented exendin-4-mediated insulin secretion in diabetic db/db mice.
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