Elucidation of mechanism by which FSP27 regulates insulin sensitivity by modulating fat distribution among each organ.
| Project/Area Number |
24591331
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
TAMORI YOSHIKAZU 神戸大学, 医学(系)研究科(研究院), 教授 (90379397)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 脂肪細胞 / 肥満 / インスリン抵抗性 / 脂肪滴 |
|---|
| Outline of Final Research Achievements |
FSP27 plays an important role in the efficient lipid storage in adipocytes. Expression level of FSP27 in white adipocytes reflects the ability of lipid storage in adipocytes. Excessive nutrition for a long time deteriorates hepatic steatosis and insulin resistance of FSP27 knockout mice more than control mice despite smaller adipose tissue and adipocyte size in the knockout mice. This implies that the ability of lipid storage in adipocytes is essential for the maintenance of the systemic insulin sensitivity by regulating the hepatic lipid storage independently of the adipocyte size.
|
Report
(4 results)
Research Products
(4 results)
-
[Journal Article] Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.2015
Author(s)
Zhou L, Park S, Xu L, Xia X, Ye J, Su L, Jeong K, Hur JH, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F, Yang H, Choi CS, Savage DB, Li P
-
Journal Title
Nat Commun
Volume: 6
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
