Elucidation of mechanism by which FSP27 regulates insulin sensitivity by modulating fat distribution among each organ.

Research Project

Project/Area Number	24591331
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Metabolomics
Research Institution	Kobe University
Principal Investigator	TAMORI YOSHIKAZU 神戸大学, 医学(系)研究科(研究院), 教授 (90379397)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	脂肪細胞 / 肥満 / インスリン抵抗性 / 脂肪滴
Outline of Final Research Achievements	FSP27 plays an important role in the efficient lipid storage in adipocytes. Expression level of FSP27 in white adipocytes reflects the ability of lipid storage in adipocytes. Excessive nutrition for a long time deteriorates hepatic steatosis and insulin resistance of FSP27 knockout mice more than control mice despite smaller adipose tissue and adipocyte size in the knockout mice. This implies that the ability of lipid storage in adipocytes is essential for the maintenance of the systemic insulin sensitivity by regulating the hepatic lipid storage independently of the adipocyte size.

Report

(4 results)