| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We identified novel transcriptional coactivators, PGC1αb/c, whose expression in skeletal muscle were markedly upregulated by exercise. The study of PGC1αb/c knockout mice demonstrated that these transcriptional coactivators mediate the beneficial effect of exercise on glucose and lipid metabolism, suggesting that PGC1αb/c could be a novel therapeutic targets for metabolic disease. In this study, we searched the compounds which increase the expression of PGC1αb/c in muscle cells. We also identified transcription factor X interacted with PGC1αb/c in skeletal muscle and generated skeletal muscle-specific knockout mice of transcription factor X. The analysis of these knockout mice will reveal the precise mechanism for metabolic regulation.
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