Molecular mechanism for the beneficial effect of exercise on glucose and lipid metabolism, and search for exercise mimetics
Project/Area Number |
24591332
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 運動による代謝改善作用 / 運動効果模倣薬 / 運動による糖脂質代謝改善作用の分子機構 / PGC1αb/c / 運動 / 骨格筋 / エネルギー代謝 |
Outline of Final Research Achievements |
We identified novel transcriptional coactivators, PGC1αb/c, whose expression in skeletal muscle were markedly upregulated by exercise. The study of PGC1αb/c knockout mice demonstrated that these transcriptional coactivators mediate the beneficial effect of exercise on glucose and lipid metabolism, suggesting that PGC1αb/c could be a novel therapeutic targets for metabolic disease. In this study, we searched the compounds which increase the expression of PGC1αb/c in muscle cells. We also identified transcription factor X interacted with PGC1αb/c in skeletal muscle and generated skeletal muscle-specific knockout mice of transcription factor X. The analysis of these knockout mice will reveal the precise mechanism for metabolic regulation.
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Report
(4 results)
Research Products
(22 results)