| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Stimulation of several cell types with high glucose etc. increased ER stress and inflammatory signals, and these were attenuated by MET treatment. HSP72 siRNA with MET partially decreased this attenuation.
Obese diabetic model mice were treated with or without MET for 12 weeks. BW was not altered, but visceral adiposity was particularly decreased and glucose homeostasis, insulin resistance and chronic inflammation were improved. ER stress, oxidative stress and inflammatory signals were attenuated in liver and adipose tissues. When AMPK was knockdown, this amelioration was declined. These data support that MET activates not only HSP72 expression but also AMPK phosphorylation.
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