The mechanisms of anti-inflammatory effects by the activation of heat shock response
Project/Area Number |
24591336
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Kumamoto University |
Principal Investigator |
KONDO Tatsuya 熊本大学, 大学院生命科学研究部, 助教 (70398204)
|
Co-Investigator(Kenkyū-buntansha) |
EIICHI Araki 熊本大学, 大学院生命科学研究部, 教授 (10253733)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 糖尿病 / 熱ショック応答経路 / HSP72 / AMPK / 抗炎症 / インスリン抵抗性 / 慢性炎症 / 小胞体ストレス |
Outline of Final Research Achievements |
Stimulation of several cell types with high glucose etc. increased ER stress and inflammatory signals, and these were attenuated by MET treatment. HSP72 siRNA with MET partially decreased this attenuation. Obese diabetic model mice were treated with or without MET for 12 weeks. BW was not altered, but visceral adiposity was particularly decreased and glucose homeostasis, insulin resistance and chronic inflammation were improved. ER stress, oxidative stress and inflammatory signals were attenuated in liver and adipose tissues. When AMPK was knockdown, this amelioration was declined. These data support that MET activates not only HSP72 expression but also AMPK phosphorylation.
|
Report
(4 results)
Research Products
(74 results)
-
[Journal Article] Mild electrical stimulation with heat shock reduces visceral adiposity and improves metabolic abnormalities in subjects with metabolic syndrome or type 2 diabetes: Randomized crossover trials.2014
Author(s)
Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
-
Journal Title
EBioMedicine
Volume: 1
Issue: 1
Pages: 80-89
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.2014
Author(s)
Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K.
-
Journal Title
Nat Commun.
Volume: 11
Issue: 1
Pages: 3428-3428
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.2014
Author(s)
Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E
-
Journal Title
Biochem Biophys Res Commun
Volume: 457
Issue: 1
Pages: 23-20
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] for the Tofogliflozin 004 and 005 Study group. Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials2014
Author(s)
Tanizawa Y, Kaku K, Araki E, Tobe K, Terauchi Y, Utsunomiya K, Iwamoto Y, Watada H, Ohtsuka W, Watanabe D, Suganami H
-
Journal Title
Expert Opin Pharmacother
Volume: 15(6)
Issue: 6
Pages: 749-766
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Relationship between lifestyle and lifestyle-related factors in a rural-urban population of Japan.2013
Author(s)
Zhang SC, Wei CN, Harada K, Ueda K, Fukumoto K, Matsuo H, Minamoto K, Nishikawa T, Araki E, Ueda A, Fang J
-
Journal Title
Environ Health Prev Med
Volume: 18
Issue: 4
Pages: 267-274
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Long-term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes.2013
Author(s)
Araki E, Kawamori R, Inagaki N, Watada H, Hayashi N, Horie Y, Sarashina A, Thiemann S, von Eynatten M, Dugi K, Woerle HJ
-
Journal Title
Diabetes Obes Metab
Volume: 15
Issue: 4
Pages: 364-371
DOI
Related Report
Peer Reviewed
-
[Journal Article] The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.2013
Author(s)
Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R
-
Journal Title
Nature Communications
Volume: 4
Issue: 1
Pages: 1398-1398
DOI
Related Report
Peer Reviewed
-
[Journal Article] Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy2013
Author(s)
Shimoda S, Iwashita S, Ichimori S, Matsuo Y, Goto R, Maeda T, Matsuo T, Sekigami T, Kawashima J, Kondo T, Matsumura T, Motoshima H, Furukawa N, Nishida K, Araki E.
-
Journal Title
Endocrine Journal
Volume: 60
Issue: 10
Pages: 1207-1214
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
-
[Journal Article] Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.2013
Author(s)
Miyagawa K, Kondo T, Goto R, Matsuyama R, Ono K, Kitano S, Kawasaki S, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E.
-
Journal Title
Cardiovascular Diabetology
Volume: 12(1)
Issue: 1
Pages: 160-160
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.2013
Author(s)
Matsumura T, Taketa K, Motoshima H, Senokuchi T, Ishii N, Kinoshita H, Fukuda K, Yamada S, Kukidome D, Kondo T, Hisada A, Katoh T, Shimoda S, Nishikawa T, Araki E.
-
Journal Title
Cardiovascular Diabetology
Volume: 12(1)
Issue: 1
Pages: 177-177
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis2012
Author(s)
Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
-
Journal Title
Diabetes
Volume: 61(4)
Issue: 4
Pages: 838-847
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] The impact of Ca²⁺/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells.2012
Author(s)
Suefuji M, Furukawa N, Matsumoto K, Oiso H, Shimoda S, Yoshinaga T, Matsuyama R, Miyagawa K,Kondo T, Kawashima J, Tsuruzoe K, Araki E.
-
Journal Title
Biochem Biophys Res Commun.
Volume: 421 (4)
Issue: 4
Pages: 801-807
DOI
Related Report
Peer Reviewed
-
-
-
-
[Presentation] Heat Treatment with Mild Electrical Stimulation Attenuates Systemic Inflammation and Reduces Cytokine Expression in Monocytes from subjects with Metabolic Syndrome2014
Author(s)
Tatsuya Kondo, Rina Matsuyama, Rieko Goto, Kaoru Ono, Sayaka Kitano, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki.
Organizer
The 74h Annual Meeting of American Diabetes Association
Place of Presentation
San Francisco, USA
Related Report
-
[Presentation] Activation of Heat Shock Response Improves Metabolic Profiles in Type 2 Diabetes.2013
Author(s)
atsuya Kondo, Rina Matsuyama, Rieko Goto, Kaoru Ono, Sayaka Kitano, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki.
Organizer
2013 International Conference on Diabetes and Metabolism & 5th AASD
Place of Presentation
Seoul, Korea
Related Report
Invited
-
[Presentation] Heat Shock Response Activation using Heat Treatment with Mild Electrical Stimulation Reduces Visceral Adiposity and Improves Insulin Resistance and Inflammation in Male Subjects with Type 2 Diabetes2013
Author(s)
atsuya Kondo, Rina Matsuyama, Rieko Goto, Kaoru Ono, Sayaka Kitano, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki.
Organizer
CSSI scientific meeting 2014.
Place of Presentation
Sheffield, United Kingdom
Related Report
-
[Presentation] The Role of Aldosterone in the Pathogenesis of Diabetes in Human and Rats.2013
Author(s)
Goto R, Kondo T, Ono K, Matsuyama R, Miyagawa K, Igata M, Kawashima J, Matsumura T, Motoshima H, Shimoda S, Araki E
Organizer
The 73th Annual Meeting of American Diabetes Association
Place of Presentation
Chicago, USA
Related Report
-
[Presentation] The Critical Role of Heat Shock Protein 72 in Diabetic Pathophysiology.2013
Author(s)
Matsuyama R, Kondo T, Miyagawa K, Goto R, Ono K, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E
Organizer
The 73th Annual Meeting of American Diabetes Association
Place of Presentation
Chicago, USA
Related Report
-
-
-
-
-
-
[Book] 選択的SGLT2阻害薬トホグリフロジンの臨床第Ⅲ相4試験を用いた安全性の検討. 医薬ジャーナル2015
Author(s)
加来浩平, 谷澤幸生, 荒木栄一, 綿田裕孝, 岩本安彦, 宇都宮一典, 寺内康夫, 戸邉一之, 池田勧夫, 菅波秀規, 渡邉大丞, 前田肇
Total Pages
8
Publisher
医薬ジャーナル社
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 選択的SGLT2阻害薬トホグリフロジンの腎機能別に見る有効性と安全性の検討. 医薬ジャーナル2014
Author(s)
宇都宮一典, 川浪大治, 加来浩平, 寺内康夫, 戸邉一之, 谷澤幸生, 荒木栄一, 綿田裕孝, 岩本安彦, 菅波秀規, 渡邉大丞
Total Pages
10
Publisher
医薬ジャーナル社
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-