A study of neuronal and hormonal mediations of insulin secretion by inretins.
Project/Area Number |
24591340
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | insulin secretion / incretin / diabetes / membrane potential / インスリン分泌 / 糖尿病 / 膜電位機構 / TRPチャネル / グルコース刺激インスリン分泌 / インクレチン / イオンチャネル |
Outline of Final Research Achievements |
In this stduy, we clarified the mechanistic pathway for stimulation of insulin secretion by incretins that include GLP-1 and GIP. These hormones open TRPM2 channel (transient receptor potential channe) that is a class of background current channel and its openings evoke increase in membrane excitability of pancreatic beta cells and consequently potentiate insulin secretion induced by glucose. We are expecting a novel antidiabetic drugs development as a target site against this channel protein.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.2015
Author(s)
Iwasaki, Y., Y. Maejima, S. Suyama, M. Yoshida, T. Arai, K. Katsurada, P. Kumari, H. Nakabayashi, M. Kakei, and T. Yada,
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Journal Title
Am J Physiol Regul Integr Comp Physiol.
Volume: 308
Issue: 5
Pages: R360-R369
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prediction of 90-day mortality in patients without diabetes by severe hypoglycemia: blood glucose level as a novel marker of severity of underlying disease.2015
Author(s)
Tsujimoto, T., R. Yamamoto-Honda, H. Kajio, M. Kishimoto, H. Noto, R. Hachiya, A. Kimura, M. Kakei, and M. Noda,
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Journal Title
Acta Diabetol.
Volume: 52
Issue: 2
Pages: 307-314
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion2014
Author(s)
Yoshida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M
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Journal Title
Diabetes
Volume: (Epub ahead of print)
Issue: 10
Pages: 3394-3403
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion.2014
Author(s)
Masashi Yoshida, Katsuya Dezaki, Kunitoshi Uchida, Shiho Kodera, Nien V. Lam, Kiyonori Ito, Rauza S. Rita, Hodaka Yamada, Kenju Shimomura, San-e Ishikawa, Hitoshi Sugawara, Masanobu Kawakami, Makoto Tominaga, Toshihiko Yada Masafumi Kakei1
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Journal Title
Diabetes
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Vital signs, QT prolongation, and newly diagnosed cardiovascular disease during severe hypoglycemia in type 1 and type 2 diabetic patients.2014
Author(s)
Tsujimoto T, Yamamoto-Honda R, Kajio H, Kishimoto M, Noto H, Hachiya R, Kimura A, Kakei M, Noda M:
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Journal Title
Diabetes Care
Volume: 37
Pages: 217-225
Related Report
Peer Reviewed
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[Journal Article] Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy2013
Author(s)
Ohara-Imaizumi M, Kim H, Yoshida M, Fujiwara T, Aoyagi K, Toyofuku Y, Nakamichi Y, Nishiwaki C, Okamura T, Uchida T, Fujitani Y, Akagawa K, Kakei M, Watada H, German MS, Nagamatsu S:
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110
Pages: 19420-19425
Related Report
Peer Reviewed
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[Journal Article] Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity.2013
Author(s)
Iwasaki Y1, Shimomura K, Kohno D, Dezaki K, Ayush EA, Nakabayashi H, Kubota N, Kadowaki T, Kakei M, Nakata M, Yada T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings2013
Author(s)
Yamato Kodera, S., Yoshida, M., Dezaki, K., Yada, T., Murayama, T., Kawakami, M., and Kakei, M.
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Journal Title
Endocr J
Volume: 60
Pages: 337-346
NAID
Related Report
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[Journal Article] alpha-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs2013
Author(s)
Kumazaki, M., Ando, H., Kakei, M., Ushijima, K., Taniguchi, Y., Yoshida, M., Yamato, S., Washino, S., Koshimizu, T.A., and Fujimura, A
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Journal Title
Eur J Pharmacol
Volume: 705
Pages: 1-10
Related Report
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[Journal Article] Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons2013
Author(s)
Iwasaki, Y., Kakei, M., Nakabayashi, H., Ayush, E.A., Hirano-Kodaira, M., Maejima, Y., and Yada, T.
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Journal Title
Neuropeptides
Volume: 47
Pages: 19-23
Related Report
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[Journal Article] Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet beta-cells2012
Author(s)
Damdindorj, B., Dezaki, K., Kurashina, T., Sone, H., Rita, R., Kakei, M., and Yada, T.
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Journal Title
FEBS Lett
Volume: 586
Pages: 2555-2562
Related Report
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[Presentation] Serotonin Regulates Glucose Stimulated Insulin Secretion from Pancreatic β-Cells during Pregnancy2013
Author(s)
MICA OHARA-IMAIZUMI, HAIL KIM, MASASHI YOSHIDA, YUKIKO TOYOFUKU, TADASHI OKAMURA, TOYOYOSHI UCHIDA, YOSHIO FUJITANI, MASAFUMI KAKEI, HIROTAKA WATADA, MICHAEL S. GERMAN, SHINYA NAGAMATSU,
Organizer
73rd Scientific Session of American Diabetes Association
Place of Presentation
Chicago
Related Report
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