| Project/Area Number |
24591341
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Fukushima Medical University (2014)
Jichi Medical University (2012-2013) |
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Principal Investigator |
MAEJIMA Yuko 福島県立医科大学, 医学部, 研究員 (40438669)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOMURA Kenju 福島県立医科大学, 医学部・腫瘍生体エレクトロニクス講座, 特任教授 (90636226)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 視索上核 / 室傍核 / 光 / 摂食 / オキシトシン / バソプレッシン / 視交叉上核 / 摂食リズム / ネスファチン / 肥満 / 摂食制御 |
|---|
| Outline of Final Research Achievements |
Light exposure decreased food intake, drinking, locomotor activity. These supression was related to the activation of neurons in PVN, SCN, SON and NTS. Then, AVP neurons in SCN and Oxt neurons in PVN were activated by light exposure. In addition, over 70% of neurons projects to PVN were AVP neurons. Intra AVP injection into PVN decreased food intake. AVP inhibitor attenuated the light induced anorexigenic effect. AVP activated PVN Oxt neurons, directly. From these result, light information induces anorexigenic effects via activation of AVP neurons in SCN and Oxt neurons in PVN.
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