The therapy for metabolic disorder by immune-regulation of gut microbiome.

• Project/Area Number: 24591342
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Keio University
• Principal Investigator: IRIE JUNICHIRO 慶應義塾大学, 医学部, 講師 (70306687)
• Co-Investigator(Renkei-kenkyūsha): MITSUHIRO Watanabe 慶應義塾大学, 政策・メディア研究科, 教授 (10450842)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: エネルギー代謝異常症 / 糖尿病 / 肥満症 / 腸内細菌 / メタボリックシンドローム / 腸管免疫 / 腸管環境

Outline of Final Research Achievements

Gut microbiome and intestinal immune cells interact with each other and contribute to the maintenance of host energy homeostasis by intestinal metabolites and hormone responses. The breakdown of the balance is supposed to initiate the dysregulation of energy homeostasis such as obesity and diabetes. Our findings indicate that the therapy targeting these components could be a novel strategy to resolve metabolic disorders.

Research Products

• [Journal Article] Bile acid binding resin improves hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver. (2015)
  • Author(s): Hirotsune Tagawa, Junichiro Irie, Arata Itoh, Yukie Kusumoto, Mari Kato, Nana Kobayashi, Kumiko Tanaka, Rieko Morinaga, Masataka Fujita, Yuya Nakajima, Kohkichi Morimoto, Taichi Sugizaki, Yoshinaga Kawano, Satoru Yamada, Toshihide Kawai, Mitsuhiro Watanabe, Hiroshi Itoh
  • Journal Title: Diabetes Research and Clinical Practice Volume: 印刷中 Issue: 1 Pages: 85-94
  • DOI: 10.1016/j.diabres.2015.04.025
  • Peer Reviewed
• [Journal Article] 腸内細菌と代謝異常症 (2014)
  • Author(s): 入江潤一郎、伊藤裕
  • Journal Title: 肥満研究 Volume: 20 Pages: 26-31
• [Journal Article] 腸内細菌叢と内分泌・代謝疾患 (2014)
  • Author(s): 入江潤一郎、伊藤裕
  • Journal Title: 日本内科学会雑誌 Volume: 103 Pages: 2813-2819
  • NAID: 130005108519
• [Journal Article] The Niemann-Pick C1 Like 1 (NPC1L1) Inhibitor Ezetimibe Improves Metabolic Disease Via Decreased Liver X Receptor (LXR) Activity in Liver of Obese Male Mice. (2014)
  • Author(s): Taichi Sugizaki, Mitsuhiro Watanabe, Yasushi Horai, Nao Kaneko-Iwasaki, Eri Arita, Teruo Miyazaki, Kohkichi Morimoto, Akira Honda, Junichiro Irie, Hiroshi Itoh
  • Journal Title: Endocrinology Volume: 155 Issue: 8 Pages: 2810-2819
  • DOI: 10.1210/en.2013-2143
  • Peer Reviewed
• [Journal Article] 腸内細菌叢と糖尿病・メタボリックシンドローム (2013)
  • Author(s): 入江潤一郎、伊藤裕
  • Journal Title: カレントテラピー Volume: 31 Pages: 937-942
• [Presentation] 糖尿病と腸内細菌 (2015)
  • Author(s): 入江潤一郎、伊藤裕
  • Organizer: 第49回糖尿病学の進歩
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2015-02-20 – 2015-02-21
  • Invited
• [Presentation] インクレチン・インクレチン関連薬と腸内環境 (2014)
  • Author(s): 入江潤一郎、伊藤裕
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜市開港記念会館（神奈川県横浜市）
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] 腸内細菌と腸管ホルモン (2014)
  • Author(s): 入江潤一郎、伊藤裕
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎県宮崎市）
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] 腸内細菌叢と代謝異常症 (2014)
  • Author(s): 入江潤一郎、伊藤裕
  • Organizer: 第46回日本動脈硬化学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] 腸管環境と代謝異常症 (2014)
  • Author(s): 入江潤一郎、伊藤裕
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-06-13
  • Invited
• [Presentation] 腸管分泌angptl4による新規肥満治療戦略 (2013)
  • Author(s): 楠本幸恵
  • Organizer: 日本肥満学会
  • Place of Presentation: 国際フォーラム（東京都）
• [Presentation] 胆汁酸吸着レジンの抗肥満効果における腸内細菌、腸管環境の意義
  • Author(s): 添田幸恵、入江潤一郎、田川裕恒、伊藤新、加藤麻里、小林奈奈、田中久美子、山田悟、河合俊英、尾池雄一、渡辺光博、伊藤裕
  • Organizer: 第５５回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜