Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs
| Project/Area Number |
24591343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Suguru 日本大学, 医学部, 助教 (70451614)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Mayumi 日本大学, 医学部, 講師 (80349993)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | グルカゴン / インクレチン / スルホニル尿素受容体 / DPP-4阻害薬 / メトホルミン / 膵α細胞 / 膵ランゲルハンス島 / インスリン / スルホニル尿素薬 |
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| Outline of Final Research Achievements |
Increased glucagon secretion is an essential pathogenic abnormality found in type 2 diabetes patients. In this study, we have conducted several experiments aiming to elucidate mechanisms of glucagon secretion and to apply the results for analyzing pathogenesis of type 2 diabetes in humans. We found that modulation of the sulfonylurea receptor signaling by zinc and GLP-1 could be involved in glucagon secretion, providing insights for further analysis on its mechanisms. We have also conducted a clinical study in which type 2 diabetes patients on insulin monotherapy were treated either with sitagliptin, a DPP-4 inhibitor, or metformin, a biguanide compound. We have demonstrated that sitagliptin improved glycemic control by reducing glucagon secretion. In parallel, we have compared glucagon immunoassays, and found that a newly developed glucagon ELISA revealed more dynamic changes in glucagon after a meal challenge test.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Clinical experiences in the treatment of pancreatic arteriovenous malformation by total pancreatectomy with islet autotransplantation.2013
Author(s)
Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
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Journal Title
Transplantation
Volume: 96(5)
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.2012
Author(s)
Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, Oka Y, Katagiri H.
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Journal Title
Cell Metabolism
Volume: 16(6)
Pages: 825-832
DOI
Related Report
Peer Reviewed
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