| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we examined efficient induction of mice adipocyte-derived dedifferentiated fat (DFAT) cells, which were prepared from mature adipose tissue of nonobese diabetic (NOD) mice with autoimmune type 1 diabetes. The results showed that DFAT cells prepared form NOD (NOD-DFAT) expressed same surface markers as Mesenchymal stem cells (MSC). Mice treated with NOD-DFAT cells increased their lifespan, as compared with untreated mice. MSC from human umbilical cords showed dose-dependent effect of inhibition of T cell proliferation and mRNA expression of several immunosuppressive factors. These results suggest that DFAT cells may be an attractive new immunosuppressive therapy source for cell-based therapy in young patients with type 1 diabetes.
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