| Project/Area Number |
24591347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185)
NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
HIROMINE Yoshihisa 近畿大学, 医学部, 講師 (30460851)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | １型糖尿病 / 遺伝子 / 自己免疫 / ゲノム / 膵島 / 糖尿病 |
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| Outline of Final Research Achievements |
The aim of this study was to clarify the molecular mechanisms why only beta-cells are destroyed in type 1 diabetes. Insulin-specific transcription factor, MafA, affects expression of insulin in the thymus and induction of immunological tolerance to insulin. Functional polymorphisms of MAFA were associated with type 1 diabetes. Alopecia areata, organ-specific autoimmune disease to hair follicle, was associated with autoimmune thyroid diseases, but not with type 1 diabetes, which correlated with class II HLA haplotypes susceptible or resistant to each autoimmune disease.
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