Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
It is well known that extracellular pH plays important roles in bone metabolism, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A) in bone remodeling, we generated osteoclasts and osteoblasts from bone marrow cells from pH-receptor knockout mice. These results indicate the relationship between OGR1 family and bone metabolism. We also assessed rheumatoid arthritis as in vivo model for studying acidification by accumulation of inflammatory cells.
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