Bone metabolism and its disruption in pH receptor knockout mice
Project/Area Number |
24591349
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Gunma University |
Principal Investigator |
MOGI Chihiro 群馬大学, 生体調節研究所, 助教 (00375528)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | pH / Gタンパク質共役型受容体 / 破骨細胞 / 骨芽細胞 / 関節炎 |
Outline of Final Research Achievements |
It is well known that extracellular pH plays important roles in bone metabolism, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A) in bone remodeling, we generated osteoclasts and osteoblasts from bone marrow cells from pH-receptor knockout mice. These results indicate the relationship between OGR1 family and bone metabolism. We also assessed rheumatoid arthritis as in vivo model for studying acidification by accumulation of inflammatory cells.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment.2016
Author(s)
Ichijo Y, Mochimaru Y, Azuma M, Satou K, Negishi J, Nakakura T, Oshima N, Mogi C, Sato K, Matsuda K, Okajima F, Tomura H.
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Journal Title
Biochem Biophys Res Commun.
Volume: 469
Pages: 81-6
Related Report
Acknowledgement Compliant
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[Journal Article] Protective role of proton-sensing TDAG8 in lipopolysaccharide-induced acute lung injury.2015
Author(s)
H. Tsurumaki, C. Mogi, H. Aoki-Saito, M. Tobo, Y. Kamide, M. Yatomi, K. Sato, K. Dobashi, T. Ishizuka, T. Hisada, M. Yamada, F. Okajima
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Journal Title
Int. J. Mol. Sci.
Volume: 16
Issue: 12
Pages: 28931-28942
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells.2015
Author(s)
Y. Kamide, T. Ishizuka, M. Tobo, H. Tsurumaki, H. Aoki, C. Mogi, T. Nakakura, M. Yatomi, A. Ono, Y. Koga, K. Sato, T. Hisada, K. Dobashi, M. Yamada, F. Okajima
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 464
Issue: 3
Pages: 949-955
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton- Sensing GPR4 in Extracellular Acidification-Induced Responses2015
Author(s)
Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
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Journal Title
PLoS One.
Volume: 10
Issue: 6
Pages: e0129334-e0129334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish.2015
Author(s)
Y. Mochimaru, M. Azuma, N. Oshima, Y. Ichijo, K. Satou, K. Matsuda, Y. Asaoka, H. Nishina, T. Nakakura, C. Mogi, K. Sato, F. Okajima, H. Tomura
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 457
Issue: 4
Pages: 493-499
DOI
Related Report
Peer Reviewed
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[Journal Article] Acidic pH increases cGMP accumulation through the OGR1/phospholipase C/Ca2+/neuronal NOS pathway in N1E-115 neuronal cells.2014
Author(s)
M. Kotake, K. Sato, C. Mogi, M. Tobo, H. Aoki, T. Ishizuka, N. Sunaga, H. Imai, K. Kaira, T. Hisada, M. Yamada, F. Okajima
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Journal Title
Cell. Signal.
Volume: 26
Issue: 11
Pages: 2326-2332
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model2013
Author(s)
Aoki H, Mogi C, Hisada T, Kamide Y, Ichimonji I, Tomura H, Tobo M, Sato K, Tsurumaki H, Dobashi K, Mori T, Harada H, Yamada M, Mori M, Ishizuka T, Okajima F
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Journal Title
PLoS ONE
Volume: 8(11)
Issue: 11
Pages: e79985-e79985
DOI
Related Report
Peer Reviewed
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