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Uric acid metabolism and adipocyte dysfunction in obese adipose tissue

Research Project

Project/Area Number 24591351
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionOsaka University

Principal Investigator

NISHIZAWA Hitoshi  大阪大学, 医学(系)研究科(研究院), 助教 (20379259)

Co-Investigator(Kenkyū-buntansha) FUNAHASHI Tohru  大阪大学, 大学院医学(系)研究科, 寄附講座教授 (60243234)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsプリン代謝異常 / アミノ酸代謝異常
Outline of Final Research Achievements

Obesity is often accompanied by hyperuricemia. However, purine metabolism in various tissues, especially regarding uric acid production, has not been elucidated. Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Adipose tissue was one of major organs that had abundant activities of XOR, and obese adipose tissues had higher XOR activities. Cultured adipocytes produced and secreted uric acid into culture medium. Uric acid secretion from whole adipose tissue was increased in obese mice. Our results suggest that purine catabolism in adipose tissue could be enhanced in obesity. Furthermore, we found that content of various metabolites including amino acids changed specifically in obese adipose tissue. Possibly, metabolic dysfunction may be associated with endocrine dysfunction (dysregulation of adipocytokines) in obese adipose tissue such as hypoadiponestinemia.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (38 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (23 results) (of which Invited: 8 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice.2015

    • Author(s)
      Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, Sekimoto R, Tsushima Y, Masuda S, Yamaoka M, Inoue K, Nishizawa H, Kita S, Ranscht B, Funahashi T, Shimomura I.
    • Journal Title

      Endocrinology.

      Volume: 156 Issue: 3 Pages: 934-946

    • DOI

      10.1210/en.2014-1618

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 55)Systemic arteriosclerosis and eating behavior in Japanese type 2 diabetic patients with visceral fat accumulation.2015

    • Author(s)
      Fukuda S, Hirata A, Nishizawa H, Nagao H, Kashine S, Kimura T, Inoue K, Fujishima Y, Yamaoka M, Kozawa J, Kitamura T, Yasuda T, Maeda N, Imagawa A, Funahashi T, Shimomura I.
    • Journal Title

      Cardiovasc Diabetol.

      Volume: 14 Pages: 8-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of adiponectin on cardiac beta-catenin signaling pathway under angiotensin II infusion.2014

    • Author(s)
      Fujishima Y, Maeda N, Matsuda K, Komura N, Hirata A, Mori T, Sekimoto R, Tsushima Y, Nishizawa H, Funahashi T, Shimomura I.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 444 Issue: 2 Pages: 224-229

    • DOI

      10.1016/j.bbrc.2014.01.043

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of Opa-interacting protein 5 in adipose proinflammation and obesity.2014

    • Author(s)
      Inoue K, Maeda N, Mori T, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, Funahashi T, Shimomura I.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: e87661-e87661

    • DOI

      10.1371/journal.pone.0087661

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adipose hypothermia in obesity and its association with period homolog 1, insulin sensitivity, and inflammation in fat.2014

    • Author(s)
      Yamaoka M, Maeda N, Takayama Y, Sekimoto R, Tsushima Y, Matsuda K, Mori T, Inoue K, Nishizawa H, Tominaga M, Funahashi T, Shimomura I.N
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 11 Pages: e112813-e112813

    • DOI

      10.1371/journal.pone.0112813

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Uric acid secretion from adipose tissue and its increase in obesity2013

    • Author(s)
      Tsushima Y, Nishizawa H, Tochino Y, Nakatsuji H, Sekimoto R, Nagao H, Shirakura T, Kato K, Imaizumi K, Takahashi H, Tamura M, Maeda N, Funahashi T, Shimomura I.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Issue: 38 Pages: 27138-27149

    • DOI

      10.1074/jbc.m113.485094

    • NAID

      40020225855

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity.2013

    • Author(s)
      Nagao H, Kashine S, Nishizawa H, Okada T, Kimura T, Hirata A, Fukuda S, Kozawa J, Maeda N, Kitamura T, Yasuda T, Okita K, Hibuse T, Tsugawa M, Imagawa A, Funahashi T, Shimomura I.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 12(1) Issue: 1 Pages: 88-88

    • DOI

      10.1186/1475-2840-12-88

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel role for adipose ephrin-B1 in inflammatory response2013

    • Author(s)
      Mori T, Maeda N, Inoue K, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, Funahashi T, Shimomura I
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 10 Pages: e76199-e76199

    • DOI

      10.1371/journal.pone.0076199

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] タボリックシンドロームの概念とその分子病態2012

    • Author(s)
      西澤 均、下村伊一郎
    • Journal Title

      最新臨床糖尿病学 上 日本臨牀

      Volume: 70 Pages: 47-50

    • Related Report
      2012 Research-status Report
  • [Journal Article] メタボリックシンドローム・保健指導にまつわるトピック2012

    • Author(s)
      西澤 均
    • Journal Title

      月刊 糖尿病 医学出版

      Volume: 4 Pages: 6-12

    • Related Report
      2012 Research-status Report
  • [Presentation] 肥満脂肪組織におけるアミノ酸代謝の変化2015

    • Author(s)
      長尾博文、西澤均 他
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪組織慢性炎症における免疫細胞の動態変化の解析2014

    • Author(s)
      堰本亮平、前田法一、西澤均 他
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] アディポネクチンのT-カドヘリンを介した心血管系組織集積機構の解明2014

    • Author(s)
      松田圭介、前田法一、西澤均 他
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内臓脂肪蓄積の臨床と基礎2014

    • Author(s)
      西澤 均
    • Organizer
      Hokusetsu Target Organ Protection Forum
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肥満2型糖尿病とメタボリックシンドローム2014

    • Author(s)
      西澤 均
    • Organizer
      生活習慣病セミナー2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-07-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 内臓脂肪蓄積型糖尿病患者における動脈硬化と食行動2014

    • Author(s)
      福田士郎、西澤均 他
    • Organizer
      高尿酸血症・メタボリックシンドロームリサーチフォーラム第10回研究集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] アディポネクチンの心肥大抑制作用における、β-cateninシグナルの検討2014

    • Author(s)
      藤島裕也、前田法一、西澤均 他
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満脂肪細胞における時計遺伝子Period homolog 1 (Per1)の発言制御2014

    • Author(s)
      山岡正弥、前田法一、西澤均 他
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] アディポサイトカイン異常としての高尿酸血症2014

    • Author(s)
      西澤 均
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 2型糖尿病患者における内臓脂肪蓄積と睡眠リズムの関係2014

    • Author(s)
      福田士郎、西澤均 他
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 2型糖尿病患者における腹部肥満の有無と血管合併症・体重歴の関係2014

    • Author(s)
      長尾博文、西澤均 他
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満脂肪組織慢性炎症における脂肪細胞エフリンB1の意義2014

    • Author(s)
      前田法一、西澤均 他
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪細胞増殖に関与する新規分子OIP5の解析2014

    • Author(s)
      井上佳菜、前田法一、西澤均 他
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内臓脂肪2014

    • Author(s)
      西澤 均
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウス肥満脂肪組織におけるXOR活性と尿酸代謝異常2014

    • Author(s)
      西澤 均
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満脂肪組織と尿酸代謝異常

    • Author(s)
      西澤 均
    • Organizer
      日本肥満学会 第18回アディポサイエンス・シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 脂肪組織における尿酸代謝の意義

    • Author(s)
      西澤 均
    • Organizer
      第47回日本痛風・核酸代謝学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 肥満脂肪組織におけるXOR活性と尿酸産生

    • Author(s)
      對馬佑、西澤均、栩野義博、中辻秀朗、堰本亮平、長尾博文、白倉尚、加藤賢太、今泉啓一郎、高橋洋之、田村みずほ、前田法一、船橋徹、下村伊一郎
    • Organizer
      第34回日本肥満学会年次学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 腹部肥満2型糖尿病の臨床像

    • Author(s)
      西澤均、樫根晋、南朋子など
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 指導するなら絶対必要!!生活習慣改善指導の基礎知識

    • Author(s)
      西澤均
    • Organizer
      日本肥満学会主催 より良い特定健診・保健指導のためのスキルアップ講座
    • Place of Presentation
      神戸ファッションマートKFMホール・イオ(兵庫県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 都市部における糖尿病教育入院患者の実態調査

    • Author(s)
      木村武量、西澤均など
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] 地域での血管合併症と健診・保健指導の現状と課題

    • Author(s)
      西澤均
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都府)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脂肪組織におけるXOR活性の測定と肥満に伴う上昇

    • Author(s)
      對馬佑、西澤均など
    • Organizer
      第46回日本痛風・核酸代謝学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Book] ここまで明らかになった!尿酸代謝ワールドと高尿酸血症の病態解明~診療と医学の最前線~ Chapter 5 Practice ~種々の疾患リスクとしての高尿酸血症 2. 肥満と尿酸代謝の関わり 1)肥満症・メタボリックシンドローム2015

    • Author(s)
      西澤均、船橋徹
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 尿酸と血糖 vol.1 no.1 2015 XO阻害薬とメタボリックシンドローム2015

    • Author(s)
      西澤均、下村伊一郎
    • Total Pages
      4
    • Publisher
      先端医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 診療ガイドラインUP-TO-DATE 2014-2015  肥満症2014

    • Author(s)
      西澤 均
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 医学のあゆみ 250巻9号 肥満症・メタボリックシンドロームの診断基準2014

    • Author(s)
      長尾博文、西澤均
    • Total Pages
      6
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科内分泌・代謝内科学 第3研究室

    • URL

      http://www.med.osaka-u.ac.jp/pub/endmet/www/home/labo3.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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