| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Obesity is often accompanied by hyperuricemia. However, purine metabolism in various tissues, especially regarding uric acid production, has not been elucidated. Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Adipose tissue was one of major organs that had abundant activities of XOR, and obese adipose tissues had higher XOR activities. Cultured adipocytes produced and secreted uric acid into culture medium. Uric acid secretion from whole adipose tissue was increased in obese mice. Our results suggest that purine catabolism in adipose tissue could be enhanced in obesity. Furthermore, we found that content of various metabolites including amino acids changed specifically in obese adipose tissue. Possibly, metabolic dysfunction may be associated with endocrine dysfunction (dysregulation of adipocytokines) in obese adipose tissue such as hypoadiponestinemia.
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