Uric acid metabolism and adipocyte dysfunction in obese adipose tissue
Project/Area Number |
24591351
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Osaka University |
Principal Investigator |
NISHIZAWA Hitoshi 大阪大学, 医学(系)研究科(研究院), 助教 (20379259)
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Co-Investigator(Kenkyū-buntansha) |
FUNAHASHI Tohru 大阪大学, 大学院医学(系)研究科, 寄附講座教授 (60243234)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | プリン代謝異常 / アミノ酸代謝異常 |
Outline of Final Research Achievements |
Obesity is often accompanied by hyperuricemia. However, purine metabolism in various tissues, especially regarding uric acid production, has not been elucidated. Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Adipose tissue was one of major organs that had abundant activities of XOR, and obese adipose tissues had higher XOR activities. Cultured adipocytes produced and secreted uric acid into culture medium. Uric acid secretion from whole adipose tissue was increased in obese mice. Our results suggest that purine catabolism in adipose tissue could be enhanced in obesity. Furthermore, we found that content of various metabolites including amino acids changed specifically in obese adipose tissue. Possibly, metabolic dysfunction may be associated with endocrine dysfunction (dysregulation of adipocytokines) in obese adipose tissue such as hypoadiponestinemia.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice.2015
Author(s)
Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, Sekimoto R, Tsushima Y, Masuda S, Yamaoka M, Inoue K, Nishizawa H, Kita S, Ranscht B, Funahashi T, Shimomura I.
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Journal Title
Endocrinology.
Volume: 156
Issue: 3
Pages: 934-946
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 55)Systemic arteriosclerosis and eating behavior in Japanese type 2 diabetic patients with visceral fat accumulation.2015
Author(s)
Fukuda S, Hirata A, Nishizawa H, Nagao H, Kashine S, Kimura T, Inoue K, Fujishima Y, Yamaoka M, Kozawa J, Kitamura T, Yasuda T, Maeda N, Imagawa A, Funahashi T, Shimomura I.
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Journal Title
Cardiovasc Diabetol.
Volume: 14
Pages: 8-8
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effect of adiponectin on cardiac beta-catenin signaling pathway under angiotensin II infusion.2014
Author(s)
Fujishima Y, Maeda N, Matsuda K, Komura N, Hirata A, Mori T, Sekimoto R, Tsushima Y, Nishizawa H, Funahashi T, Shimomura I.
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Journal Title
Biochem Biophys Res Commun.
Volume: 444
Issue: 2
Pages: 224-229
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Possible involvement of Opa-interacting protein 5 in adipose proinflammation and obesity.2014
Author(s)
Inoue K, Maeda N, Mori T, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, Funahashi T, Shimomura I.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: e87661-e87661
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Adipose hypothermia in obesity and its association with period homolog 1, insulin sensitivity, and inflammation in fat.2014
Author(s)
Yamaoka M, Maeda N, Takayama Y, Sekimoto R, Tsushima Y, Matsuda K, Mori T, Inoue K, Nishizawa H, Tominaga M, Funahashi T, Shimomura I.N
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Journal Title
PLoS One.
Volume: 9
Issue: 11
Pages: e112813-e112813
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Uric acid secretion from adipose tissue and its increase in obesity2013
Author(s)
Tsushima Y, Nishizawa H, Tochino Y, Nakatsuji H, Sekimoto R, Nagao H, Shirakura T, Kato K, Imaizumi K, Takahashi H, Tamura M, Maeda N, Funahashi T, Shimomura I.
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Journal Title
Journal of Biological Chemistry
Volume: 288
Issue: 38
Pages: 27138-27149
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity.2013
Author(s)
Nagao H, Kashine S, Nishizawa H, Okada T, Kimura T, Hirata A, Fukuda S, Kozawa J, Maeda N, Kitamura T, Yasuda T, Okita K, Hibuse T, Tsugawa M, Imagawa A, Funahashi T, Shimomura I.
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Journal Title
Cardiovasc Diabetol
Volume: 12(1)
Issue: 1
Pages: 88-88
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel role for adipose ephrin-B1 in inflammatory response2013
Author(s)
Mori T, Maeda N, Inoue K, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, Funahashi T, Shimomura I
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Journal Title
PLoS ONE
Volume: 8
Issue: 10
Pages: e76199-e76199
DOI
Related Report
Peer Reviewed
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[Presentation] 内臓脂肪2014
Author(s)
西澤 均
Organizer
第87回日本内分泌学会学術総会
Place of Presentation
福岡
Year and Date
2014-04-25
Related Report
Invited
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