| Project/Area Number |
24591354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
YAGYU Hiroaki 自治医科大学, 医学部, 非常勤講師 (60348018)
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Hiroaki 東京大学, 医学部附属病院, 助教 (80610211)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Manabu 自治医科大学, 医学部, 助教 (70406122)
NAGASHIMA Syuichi 自治医科大学, 医学部, 助教 (30406136)
ISHIBASHI Shun 自治医科大学, 医学部, 教授 (90212919)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | リポ蛋白リパーゼ / 肝臓 / 脂質代謝 |
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| Outline of Final Research Achievements |
Floxed LpL mice used as control and liver specific LpL knockout (L-LpLKO) mice were fed with the diets containing T0901317 for 2 weeks to induce the lipogenesis and the expression of LpL in the liver. T0901317 led to a significant 45% decrease of hepatic LpL activity in L-LpLKO mice compared to control mice. The LpL activities in the skeletal muscle, heart, adipose tissue and plasma were not influenced by T0901317 and those activities were similar between two types of mice. Although T0901317 increased VLDL-TG in both mice, L-LpLKO mice had more VLDL-TG than control mice. T0901317 increased HDL in control mice, but not L-LpLKO mice. VLDL production was similar in both mice. T0901317 induced TG accumulations in the liver, with no significant difference between two types of mice. In conclusion, although further investigation should be considered to determine the role of hepatic LpL on the fatty liver, hepatic LpL could be involved in VLDL and HDL metabolisms.
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