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Glucose regulates the function of glucocorticoid receptor via O-GlcNAc modification.

Research Project

Project/Area Number 24591357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionThe University of Tokushima (2013-2014)
Gunma University (2012)

Principal Investigator

SAWATSUBASHI Shun  徳島大学, 藤井節郎記念医科学センター, 特任講師 (70535103)

Co-Investigator(Renkei-kenkyūsha) KITAGAWA Hirochika  群馬大学, 生体調節研究所, 教授 (20345234)
SATO Takashi  群馬大学, 生体調節研究所, 准教授 (70344934)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsグルココルチコイド / 翻訳後修飾 / O-GlcNAc / 核内受容体 / ステロイドホルモン / グルココルチコイドレセプター / GR / O-GlcNAc修飾 / OGT / グルココルチコイド受容体 / O-GlcNAc転移酵素 / グルコース / リン酸化 / 転写
Outline of Final Research Achievements

Glucocorticoids are widely used as anti-inflammatory drugs, the molecular mechanisms involved in this anti-inflammatory effect and associated with serious side effects remain unknown. In this study, we performed the proteomic analysis of post-translational modification on glucocorticoid receptor (GR) and identified a novel O-linked beta-N-acetylglucosamine (O-GlcNAc) modified sites. Moreover, this O-GlcNAcylation was regulated under conditions of glucose concentration in culture medium and detected in nucleus of mouse liver and cerebrum. Based on these results, we propose that this O-GlcNAcylation regulates the tissue-specific transcriptional activity of GR.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Epigenetic Silencing of Core Histone Genes by HERS in Drosophila2012

    • Author(s)
      Ito S., et al.,
    • Journal Title

      Molecular Cell

      Volume: 45 Issue: 4 Pages: 494

    • DOI

      10.1016/j.molcel.2011.12.029

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] O-GlcNAc転移酵素(OGT)によるグルココルチコイドレセプター(GR)の転写制御機構の解析2014

    • Author(s)
      沢津橋俊
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 栄養情報が制御するグルココルチコイドレセプター機能切り換えの分子メカニズム解析

    • Author(s)
      沢津橋 俊
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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