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Molecular immunological study focussing on cerebral vasculitis in Hashimoto's encephalopathy associated with chronic thyroiditis

Research Project

Project/Area Number 24591358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionFukui Prefectural University (2013-2014)
University of Fukui (2012)

Principal Investigator

YONEDA Makoto  福井県立大学, 看護福祉学部, 教授 (70270551)

Co-Investigator(Kenkyū-buntansha) TAKAMURA Toshinari  金沢大学, 医学系, 教授 (00324111)
IKAWA Masamichi  福井大学, 医学部付属病院, 助教 (60444212)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords橋本脳症 / 自己抗体 / 脳血管炎 / SPECT画像 / プロテオーム / 血管炎 / 脳血流 / 脳血流SPECT
Outline of Final Research Achievements

We focused on the cerebral vasculitis in Hashimoto’s encephalopathy (HE) associated with chronic thyroiditis in this research. We evaluated the changes in regional cerebral blood flow (rCBF) between 7 cases of HE with anti-NAE autoantibodies, a useful diagnostic marker of HE, and 10 controls using brain SPECT by 3D-SSP analysis. The rCBF of patients with HE was significantly decreased in the bilateral anterior cingulate areas and left prefrontal cortex compared with the controls, in which both brain areas are closely related to memory disturbance and psychosis. We further evaluated the changes in proteomes after the supplementation of sera from patients with HE to a human cerebral endothelial cultured cells, and demonstrated significant decreases in several proteomes. These data strongly suggests that cerebral vasculitis plays a crucial role in the pathogenesis of HE.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (37 results)

All 2015 2014 2013 2012

All Journal Article (23 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) Book (8 results)

  • [Journal Article] Consensus Paper: NeuroimmuneMechanisms of Cerebellar Ataxias2015

    • Author(s)
      Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H,Nanri K, Shanmugarajah P, Yoneda M, Yuki N.
    • Journal Title

      Cerebellum

      Volume: on line Issue: 2 Pages: 213-32

    • DOI

      10.1007/s12311-015-0664-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 橋本脳症.α-エノラーゼ,自己免疫性脳炎:抗原・抗体は何をしている?2015

    • Author(s)
      米田誠
    • Journal Title

      Clin Neurosci

      Volume: 33 Pages: 104-107

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 橋本脳症.Ⅱ.知っておきたい神経疾患2015

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      精神科

      Volume: 26 Pages: 159-163

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Presynaptic dysfunction caused by CSF from a patient with ataxic form of Hashimoto’s encephalopathy2014

    • Author(s)
      Hiroshi Mitoma, Makoto Yoneda, Fumito Saitow, Hidenori Suzuki, Akiko Matsunaga, Masamichi Ikawa, Hidehiro Mizusawa
    • Journal Title

      Neurol Clin Neurosci

      Volume: 2 Issue: 4 Pages: 104-108

    • DOI

      10.1111/ncn3.105

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 免疫性神経疾患の新しい展開 脳から自律神経障害まで -自己免疫性脳炎とその周辺-2014

    • Author(s)
      米田誠
    • Journal Title

      臨床神経

      Volume: 53 Pages: 1059-1062

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] 橋本脳症2014

    • Author(s)
      米田誠
    • Journal Title

      日本臨床Ⅱ(別冊)

      Volume: 27 Pages: 713-716

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] 小脳失調症.こんな神経症状から始まる悪性腫瘍 -傍腫瘍性小脳失調症の実態-2014

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      成人病と生活習慣病

      Volume: 44 Pages: 401-405

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 甲状腺機能低下症2014

    • Author(s)
      榎本宗一,松永晶子,米田誠
    • Journal Title

      日本臨床Ⅴ(別冊)

      Volume: 5 Pages: 219-223

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 甲状腺機能亢進症2014

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      日本臨床Ⅴ

      Volume: 5 Pages: 214-218

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 橋本脳症2014

    • Author(s)
      米田誠
    • Journal Title

      日本臨床Ⅴ(別冊)

      Volume: 5 Pages: 224-227

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 橋本脳症 –病因・病態と診断・治療-2014

    • Author(s)
      米田誠
    • Journal Title

      Medical Practice (MP)

      Volume: 31 Pages: 1766-1770

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Pathophysiological Decrease in the Regional Cerebral Blood Flow in Hashimoto’s Encephalopathy: A Multiple-Case SPECT Study.2014

    • Author(s)
      Tomoko Muramatsu, Masamichi Ikawa, Makoto Yoneda, Katsuya Sugimoto, Akiko Matsunaga, Osamu Yamamura., Tadanori Hamano, Hidehiko Okazawa, Yasunari Nakamoto
    • Journal Title

      Eur Neurol

      Volume: 72 Issue: 1-2 Pages: 13-19

    • DOI

      10.1159/000358220

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodic synchronous dischargeを呈しCreutzfeldt-Jakob病との識別を要した橋本脳症の1例.2013

    • Author(s)
      村松倫子,濱野忠則,白藤法道,松永晶子,井川正道,米田誠
    • Journal Title

      臨床神経学

      Volume: 53 Pages: 716-720

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 橋本脳症のバイオマーカーと治療.2013

    • Author(s)
      岸谷融,松永晶子,米田誠.
    • Journal Title

      日本臨床

      Volume: 71 Pages: 893-897

    • Related Report
      2013 Research-status Report
  • [Journal Article] 橋本脳症2013

    • Author(s)
      米田誠
    • Journal Title

      分子精神医学

      Volume: 13 Pages: 178-184

    • Related Report
      2013 Research-status Report
  • [Journal Article] 自己免疫性脳炎2013

    • Author(s)
      米田誠
    • Journal Title

      内科学会雑誌

      Volume: 102 Pages: 2060-2064

    • Related Report
      2013 Research-status Report
  • [Journal Article] 抗NAE(NH2-terminal of α-enolase)抗体と進行性小脳失調.2013

    • Author(s)
      松永晶子,米田誠
    • Journal Title

      神経内科

      Volume: 79 Pages: 334-340

    • Related Report
      2013 Research-status Report
  • [Journal Article] 橋本脳症2013

    • Author(s)
      米田誠
    • Journal Title

      日本臨床II

      Volume: 27 Pages: 713-716

    • Related Report
      2013 Research-status Report
  • [Journal Article] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration2013

    • Author(s)
      Matsunaga A, Ikawa M, Fujii A, Nakamoto Y, Kuriyama M, Yoneda M
    • Journal Title

      Eur. Neurol

      Volume: 69 Issue: 1 Pages: 14-20

    • DOI

      10.1159/000342217

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hashimoto’s encephalopathy with hippocampus involvement detected on continuous arterial spin labeling2013

    • Author(s)
      Ishitobi M, Yoneda M, Ikawa M, Matsunaga A, Ueno K, Kimura H, Wada Y
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 67 Issue: 2 Pages: 128-129

    • DOI

      10.1111/pcn.12019

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 橋本脳症と自己抗体.2013

    • Author(s)
      米田誠
    • Journal Title

      Brain & Nerve

      Volume: 65 Pages: 365-376

    • Related Report
      2012 Research-status Report
  • [Journal Article] 橋本脳症の治療指針.2012

    • Author(s)
      米田誠
    • Journal Title

      臨床神経

      Volume: 52 Pages: 1240-1242

    • Related Report
      2012 Research-status Report
  • [Journal Article] 小脳失調型橋本脳症.2012

    • Author(s)
      米田誠
    • Journal Title

      臨床神経

      Volume: 52 Pages: 1369-1371

    • Related Report
      2012 Research-status Report
  • [Presentation] Pathophysiological Decrease in the Regional Cerebral Blood Flow in Hashimoto’s Encephalopathy: A Multiple-Case SPECT Study2015

    • Author(s)
      Masamichi Ikawa, Tomoko Muramatsu, Katsuya Sugimoto, Akiko Matsunaga, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Hidehiko Okazawa, Makoto Yoneda
    • Organizer
      The 68th Annual meeting of American Academy of Neurology
    • Place of Presentation
      Washington, USA
    • Year and Date
      2015-04-18 – 2015-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical and immunological features of limbic form of Hashimoto’s encephalopathy2015

    • Author(s)
      Toru Kishitani, Akiko Matsunaga, Masamichi Ikawa, Tomomi Kame, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Makoto Yoneda
    • Organizer
      The 68th Annual meeting of American Academy of Neurology
    • Place of Presentation
      Washington, USA
    • Year and Date
      2015-04-18 – 2015-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical and immunological features of Hashimoto’s encephalopathy presenting with limbic symptoms.2014

    • Author(s)
      Akiko Matsunaga, Toru Kishitani, Tomoko Muramatsu, Tomomi Kame, Masamichi Ikawa, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamot, Makoto Yoneda
    • Organizer
      The 67th Annual meeting of American Academy of Neurology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-04-26 – 2014-05-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical and immunological features of Hashimoto’s encephalopathy presenting with limbic symptoms.2014

    • Author(s)
      Akiko Matsunaga,, Toru Kishitani, Tomoko Muramatsu, Tomomi Kame, Masamichi Ikawa, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Makoto Yoneda
    • Organizer
      The 66th Annual Meeting of AAN
    • Place of Presentation
      Philadelphia, PA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Hashimoto’s encephalopathy associated with anti-NAE autoantibodies; analysis of 101 patients.2013

    • Author(s)
      Akiko Matsunaga, Toru Kishitani, Tomoko Muramatsu, Tomomi Kame, Masamichi Ikawa, Yasunari Nakamoto, Makoto Yoneda
    • Organizer
      The 65th Annual Meeting of AAN
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Hashimoto’s encephalopathy as treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration.2013

    • Author(s)
      Kishitani T, Matsunaga A, Kame T, Ikawa M, Nakamoto Y, Yoneda M
    • Organizer
      The 65th Annual Meeting of AAN, San Diego, USA
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Book] 橋本脳症.シリーズ《アクチュアル 脳・神経疾患の臨床》『免疫性神経疾患 病態と治療のすべて 』免疫性神経疾患2015

    • Author(s)
      米田誠
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Book] 小脳失調症に免疫療法は有用か.シリーズ《アクチュアル 脳・神経疾患の臨床》『免疫性神経疾患 病態と治療のすべて 』免疫性神経疾患2015

    • Author(s)
      南里和紀,米田誠
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Book] 免疫性神経疾患ハンドブック(分担)橋本脳症2013

    • Author(s)
      米田誠
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2013 Research-status Report
  • [Book] 神経・精神疾患診療マニュアル(分担)甲状腺疾患2013

    • Author(s)
      米田誠
    • Total Pages
      2
    • Publisher
      日本医師会
    • Related Report
      2013 Research-status Report
  • [Book] 橋本脳症.今日の神経疾患治療指針2013

    • Author(s)
      米田誠
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 甲状腺機能亢進症.今日の神経疾患治療指針2013

    • Author(s)
      米田誠
    • Total Pages
      4
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 自己免疫性小脳失調症.Annual Review 2013神経.2013

    • Author(s)
      松永晶子,米田誠
    • Total Pages
      7
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] 橋本脳症.今日の精神疾患治療指針2012

    • Author(s)
      米田誠
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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