Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor
Project/Area Number |
24591359
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | University of Yamanashi |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANESHIGE Masahiro 山梨大学, 総合研究部, 助教 (20377518)
KOBAYASHI Tetsuro 公益財団法人冲中記念成人病研究所, 研究室, 研究員 (30113442)
SHIMURA Hiroki 福島県立医科大学, 医学部, 教授 (40303416)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 内分泌 / 内分泌学 / 小胞体ストレス / 糖尿病 / 膵再生 |
Outline of Final Research Achievements |
In control adenovirus-infected pancreatic β-cells, palmitate enhanced the expression of ATF4 and heme oxygenase 1, which facilitates adaptation to oxidative ER stress. However, in AdshTRα-infected pancreatic β-cells, palmitate did not induce ATF4-mediated integrated stress response, and oxidative stress-associated apoptotic cell death was significantly enhanced. TRα-deficient mice or WT were fed a HFD for 30 weeks, and the effect of oxidative ER stress on pancreatic β-cells was analyzed. HFD-treated TRα-deficient mice had high blood glucose levels and low plasma insulin levels. In HFD-treated TRα-deficient mice, ATF4 was not induced, and apoptosis was enhanced compared with HFD-treated WT mice. These results indicate that endogenous TRα plays an important role for the expression of ATF4 and facilitates reduced apoptosis in pancreatic β-cells under ER stress.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients.2014
Author(s)
Furuya F, Shimura H, Yokomichi H, Takahashi K, Akiyama D, Asakawa C, Okamura A, Motosugi A, Haraguchi K, Yamagata Z, Kobayashi T.
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Journal Title
Clin Exp Nephrol.
Volume: 18
Pages: 778-783
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients2014
Author(s)
Furuya F, Shimura H, Yokomichi H, Takahashi K, Akiyama D, Asakawa C, Okamura A, Motosugi A, Haraguchi K, Yamagata Z, Kobayashi T.
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Journal Title
Clin Exp Nephrol
Volume: 12
Related Report
Peer Reviewed
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