Etiology of fulminant type 1 diabetes mellitus
| Project/Area Number |
24591362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
IMAGAWA AKIHISA 大阪大学, 医学(系)研究科(研究院), 准教授 (80373108)
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| Co-Investigator(Renkei-kenkyūsha) |
HANAFUSA Toshiaki 大阪医科大学, 医学部, 教授 (60164886)
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| Research Collaborator |
FUKUI Kenji
NAKATA Shinsuke
YOSHIKAWA Atsushi
HOSOKAWA Yoshiya
BADEN Megu
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 1型糖尿病 / １型糖尿病 / 劇症１型糖尿病 / NK細胞 / KLRC3 / CD94 |
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| Outline of Final Research Achievements |
The aim of the present study was to determine the significance of ISG15, which is induced by viral infection, and KLRC3, which is known as an activating receptor of NK cells in the development of fulminant type 1 diabetes mellitus.
We found that ISG15 acted as an inhibitor of apoptosis by inflammatory cytokines by using overexpression and knockdown methods in MIN6 cells, mouse beta cell line. We also found that the gene expressions of KLRC3 (NKG2E) and CD94, its heterodimer, were reduced in peripheral NK cells of fulminant type 1 diabetic patients.
Overall, we have clarified two candidates of key molecules in the beta cell destruction of fulminant type 1 diabetes.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Interferon stimulated gene 15 has an anti-apoptotic effect on MIN6 cells2014
Author(s)
Yoshikawa A, Imagawa A, Nakata S, Fukui K, Kuroda Y, Miyata Y, Sato Y, Hanafusa T, Matsuoka TA, Kaneto H, Iwahashi H, Shimomura I.
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Journal Title
Endocrine Journal
Volume: 61
Issue: 9
Pages: 883-890
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Low gene expression levels of activating receptors of natural killer cells (NKG2E and CD94) in patients with fulminant type 1 diabetes.2013
Author(s)
Nakata S, Imagawa A, Miyata Y, Yoshikawa, Kozawa J, Okita K, Funahashi T, Nakamura S, Matsubara K, Iwahashi H, Shimomura I.
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Journal Title
Immunol Lett
Volume: 156
Issue: 1-2
Pages: 149-155
DOI
Related Report
Peer Reviewed
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[Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New Diagnostic Criteria of Fulminant Type 1 Diabetes Mellitus（2012）2012
Author(s)
Imagawa A, Hanafusa T, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawasaki E, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Maruyama T
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Journal Title
Diabetology International
Volume: 3
Issue: 4
Pages: 179-179
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] 劇症1型糖尿病の新しい診断基準(2012)2012
Author(s)
今川 彰久, 花房 俊昭, 粟田 卓也, 池上 博司, 内潟 安子, 大澤 春彦, 川崎 英二, 川畑 由美子, 小林 哲郎, 島田 朗, 清水 一紀, 高橋 和眞, 永田 正男, 牧野 英一, 丸山 太郎
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Journal Title
糖尿病
Volume: 55(10)
Pages: 815-820
Related Report
Peer Reviewed
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[Presentation] 劇症１型糖尿病2014
Author(s)
今川彰久
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪市
Year and Date
2014-05-22 – 2014-05-24
Related Report
Invited
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[Presentation] 劇症１型糖尿病の成因2014
Author(s)
今川彰久、花房俊昭
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪市
Year and Date
2014-05-22 – 2014-05-24
Related Report
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[Presentation] 劇症1型糖尿病患者膵島領域に発現する蛋白の同定(第三報) ISG15の機能解析2014
Author(s)
芳川 篤志, 今川 彰久, 中田 伸輔, 宇野 彩, 福井 健司, 黒田 陽平, 宮田 佑吾, 佐藤 叔史, 花房 俊昭, 松岡 孝昭, 金藤 秀明, 岩橋 博見, 下村 伊一郎
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪市
Year and Date
2014-05-22 – 2014-05-24
Related Report
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