Investigation of the new paradigm of BMP network in the ovarian follicle.
Project/Area Number |
24591364
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Okayama University |
Principal Investigator |
OTSUKA FUMIO 岡山大学, 医歯(薬)学総合研究科, 教授 (40362967)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 卵巣 / ステロイド / 生殖 / 骨形成蛋白 / 細胞増殖因子 / 生殖内分泌 / BMP / ステロイド合成 |
Outline of Final Research Achievements |
In the present study, using rat primary cell culture, it was revealed that estrogen amplifies FSH receptor activity by modulating GRK system on granulosa cells via estrogen receptors on the oocytes. A functional loop of kit ligand and c-kit between granulosa cells and oocytes was also key for the regulation of estrogen productivity in the follicles. In addition, melatonin action in the ovary was uncovered to be involved in the enhancement of progesterone production regulated by BMPs. The circulating BMP-9 was also discovered as a new luteinizing inhibitor in this study. Furthermore, not only in the ovary, the BMP system was revealed to be involved in the regulation of kisspeptin action for GnRH regulation in the central reproductive system.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells.2013
Author(s)
Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H.
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Journal Title
Mol Cell Endocrinol.
Volume: 381
Issue: 1-2
Pages: 8-15
DOI
Related Report
Peer Reviewed
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[Presentation] A novel interaction of kisspeptin, estrogen and BMP-4 in GnRH regulation by GT1-7 cells.2013
Author(s)
Terasaka T, Otsuka F, Tsukamoto N, Toma K, Nakamura E, Inagaki K, Ogura-Ochi K, Mark A. Lawson, Makino H
Organizer
The Endocrine Society's 95th Annual Meeting
Place of Presentation
San Francisco, CA, USA
Related Report
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[Presentation] Inhibitory effects of melatonin on adrenocorticotropin production via BMP-4 activation by pituitary corticotrope cells.2013
Author(s)
Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H
Organizer
The Endocrine Society's 95th Annual Meeting
Place of Presentation
San Francisco, CA, USA
Related Report
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[Presentation] Effects of BMP-6 on Aldosterone Production by Rat Adrenal Gland In Vivo.2012
Author(s)
Miyoshi T, Otsuka F, Matsumoto Y, Inagaki K, Tsukamoto N, Nakamura E, Takano M, Ochi K, Takeda M, Makino H.
Organizer
THE ENDOCRINE SOCIETY’S 94th ANNUAL MEETING
Place of Presentation
Houston, TX, USA
Related Report
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[Presentation] Regulatory Role of Melatonin and BMP-4 in Prolactin Secretion by Rat Pituitary Lactotrope Cells.2012
Author(s)
Ochi K, Otsuka F, Tsukamoto N, Miyoshi T, Nakamura E, Takeda M, Inagaki K, Ogura T, Iwasaki Y, Makino H.
Organizer
THE ENDOCRINE SOCIETY’S 94th ANNUAL MEETING
Place of Presentation
Houston, TX, USA
Related Report
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