Do thyroid cancer risk factors FOXE1 and NKX2-1 influence risk of development of a benign adenoma?
| Project/Area Number |
24591369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAENKO Vladimir 長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Masahiro 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
MITSUTAKE Norisato 長崎大学, 原爆後障害医療研究所, 准教授 (50404215)
ITO Masahiro 独立行政法人国立病院機構, 長崎医療センター 臨床検査科, 部長 (30184691)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内分泌学 / 甲状腺腫瘍 / 遺伝子多型 |
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| Outline of Final Research Achievements |
Association analysis of five SNPs previously reported to confer risk for thyroid cancer with benign follicular adenoma (FA) was performed in 959 FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls from Japan.
A significant association was found between FA and rs944289 (PTCSC3) and rs2439302 (NRG1), demonstrating that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and implying broader roles of the pathways that NRG1 and PTCSC3 underlie in thyroid tumorigenesis, not limited to carcinogenesis.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] The common genetic variant rs944289 on chromosome 14q13.3 associates with risk of both malignant and benign thyroid tumors in the Japanese population.2015
Author(s)
Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nishihara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA.
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Journal Title
Thyroid
Volume: 25
Issue: 3
Pages: 333-340
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report2012
Author(s)
Stanojevic B, Dzodic R, Saenko V, Milovanovic Z, Krstevski V, Radlovic P, Buta M, Rulic B, Todorovic L, Dimitrijevic B, Yamashita S
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Journal Title
BMC Cancer
Volume: 12(1)
Issue: 1
Pages: 224-224
DOI
Related Report
Peer Reviewed
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[Presentation] Rare T allele of rs944289 associates not only with risk of malignant but also of benign thyroid tumors2014
Author(s)
ログノビッチ タチアナ, サエンコ ウラジミール, ビチコブ アンドレイ, ニキツキ― アリャクサンドル, 高橋めい子, 中島正洋, 林徳眞吉, 廣川満良, 宮内昭, 石垣克, 重松和人, 松瀬美智子, 光武範吏, 西原永潤, 南恵樹, 山内孝彰, 伊東正博, 吉浦孝一郎, 松田文彦, 山下俊一
Organizer
第87回 日本内分泌学会学術総会
Place of Presentation
福岡国際会議場・福岡サンパレス（福岡県・福岡市）
Year and Date
2014-04-24 – 2014-04-26
Related Report
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[Presentation] Association of polymorphism in the FOXE1 gene locus with papillary thyroid carcinoma in Japanese patients2014
Author(s)
V.Saenko, T.Rogounovitch, A.Bychkov, N.Mitsutake, M.Matsuse, E.Nishihara, M.Hirokawa, A.Nikitsky, S.Minami, K.Yamanouchi, K.Yoshiura, A.Miyauchi, S.Yamashita
Organizer
第87回 日本内分泌学会学術総会
Place of Presentation
福岡国際会議場・福岡サンパレス（福岡県・福岡市）
Year and Date
2014-04-24 – 2014-04-26
Related Report
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[Presentation] Association of the NRG1 gene with risk for developing thyroid cancer after Chernobyl.2013
Author(s)
Saenko V, Takahashi M, Rogounovitch T, Drozd V, Demidchik Yu, Bogdanova T, Tronko M, Mitsutake N, Takamura N, Takahashi J, Matsuda F, Yamashita S
Organizer
第86回日本内分泌学会学術総会
Place of Presentation
仙台国際センター（宮城）
Related Report
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[Presentation] Association of three polymorphisms of the FOXE1 gene with papillary thyroid carcinoma in Belarussian and Japanese populations.2013
Author(s)
サエンコ ウラジミール, 高橋めい子, ログノビッチ タチアナ, ドロズド ワレンチナ, ビチコブ アンドレイ, 川口喬久, 光武範吏, 廣川満良, 西原永潤, 宮内昭, 吉浦孝一郎, 松田文彦, 山下俊一
Organizer
第56回日本甲状腺学会学術集会
Place of Presentation
和歌山県民文化会館（和歌山）
Related Report
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[Presentation] Genetic polymorphism on chromosome 14q13.3 associates with risk for thyroid follicular adenoma in Japanese patients.2013
Author(s)
ログノビッチ タチアナ, サエンコ ウラジミール, ビチコブ アンドレイ, ニキツキ― アリャクサンドル, 高橋めい子, 中島正洋, 林徳眞吉, 廣川満良, 宮内昭, 石垣克, 重松和人, 光武範吏, 伊東正博, 松田文彦, 山下俊一
Organizer
第56回日本甲状腺学会学術集会
Place of Presentation
和歌山県民文化会館（和歌山）
Related Report
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