| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Paraventricular hypothalamus (PVH) is implicated in the selection of high carbohydrate diet (HCD) and high fat diet (HFD). I clarified that AMP-activated protein kinase (AMPK) in corticotropin releasing hormone, CRH neurons of PVH are critical for food selection whether HCD or HFD. CRH is well-known as stress responsible hormone. Social defeat stress also induced carbohydrate selection rather than fat intake. Inhibition of CRH expression using shRNA technique could completely disappear this preference change. Also the CRH neuron-specific inhibition of AMPK mRNA expression or neuronal activity, using DREADD system, significantly abolished stress induced food preference change. These results reveal a novel role of AMPK in CRH neurons of PVH in food selection behaviour under stress conditions.
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