| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Rat thyroid FRTL-5 cells or primary culture of mouse thyroid cells were stimulated by electric pulse to induce cell damage, or transfected with human herpes virus genomic DNA or synthetic double-stranded polynuclerotides. After these treatments, expression of series of genes essential for innate and acquired immune responses was induced. However, thyroglobulin gene expression and iodine uptake were suppressed by these treatments. These results suggest that when immune functions of thyroid cells are activated upon infection or tissue damage, thyroid hormone biosynthesis may be suppressed. Further studies are needed to confirm this possibility.
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