Effects of innate immune activation induced by infection or tissue damage on the development of thyroid autoimmunity
| Project/Area Number |
24591375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
SUZUKI Koichi 国立感染症研究所, 感染制御部, 室長 (20206478)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 甲状腺 / 自然免疫 / dsDNA / サイログロブリン / 獲得免疫 |
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| Outline of Final Research Achievements |
Rat thyroid FRTL-5 cells or primary culture of mouse thyroid cells were stimulated by electric pulse to induce cell damage, or transfected with human herpes virus genomic DNA or synthetic double-stranded polynuclerotides. After these treatments, expression of series of genes essential for innate and acquired immune responses was induced. However, thyroglobulin gene expression and iodine uptake were suppressed by these treatments. These results suggest that when immune functions of thyroid cells are activated upon infection or tissue damage, thyroid hormone biosynthesis may be suppressed. Further studies are needed to confirm this possibility.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Demonstration of innate immune responses in the thyroid gland: potential to sense danger and a possible trigger for autoimmune reactions2013
Author(s)
Kawashima A, Yamazaki K, Hara T, Akama T, Yoshihara A, Sue M, Tanigawa K, Wu H, Ishido Y, Takeshita F, Ishii N, Sato K, Suzuki K
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Journal Title
Thyroid
Volume: 23
Issue: 4
Pages: 477-487
DOI
Related Report
Peer Reviewed
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[Journal Article] Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum2013
Author(s)
Sue M, Hayashi M, Kawashima A, Akama T, Tanigawa K, Yoshihara A, Hara T, Ishido Y, Ito T, Takahashi S-I, Ishii N and Suzuki K
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Journal Title
Biochem Biophys Res Commun
Volume: 420
Issue: 3
Pages: 611-615
DOI
Related Report
Peer Reviewed
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[Journal Article] Phosphatidylinositol 3-kinase binding protein, PITKAP/XB130 is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.2012
Author(s)
Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S-I.
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Journal Title
Mol Endocrinol
Volume: 26
Issue: 6
Pages: 1043-1055
DOI
Related Report
Peer Reviewed
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[Journal Article] Propylthiouracil increases sodium/iodide symporter gene expression and iodide uptake in rat thyroid cells in the absence of TSH2012
Author(s)
Sue M, Akama T, Kawashima A, Nakamura H, Hara T, Tanigawa K, Wu H, Yoshihara A, Ishido Y, Hiroi N, Yoshino G, Kohn LD, Ishii N, and Suzuki K
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Journal Title
Thyroid
Volume: 22
Issue: 8
Pages: 844-852
DOI
Related Report
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[Journal Article] Regulation of dual oxidase (DUOX) expression and H2O2 production by thyroglobulin2012
Author(s)
Yoshihara A, Hara T, Kawashima A, Akama T, Tanigawa K, Wu H, Sue M, Ishido Y, Hiroi N, Ishii N, Yoshino G, Suzuki K
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Journal Title
Thyroid
Volume: 22
Issue: 10
Pages: 1054-1062
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of microRNAs that mediate thyroid cell growth induced by TSH2011
Author(s)
Akama T, Sue M, Kawashima A, Wu H, Tanigawa K, Suzuki S, Hayashi M, Yoshihara A, Ishido Y, Ishii N, Suzuki K
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Journal Title
Mol Endocrinol
Volume: 26
Issue: 3
Pages: 823-831
DOI
Related Report
Peer Reviewed
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