| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To understand the molecular basis of hematopoietic differentiation from human pluripotent stem cell included human embryonic stem cells and human induced pluripotent stem cells, we first analyzed a hematopoietic phenotype and gene expression on human ES-derived hematopoietic progenitor cells. As a result, hematopoietic progenitor cells with long-term culture showed developmental maturation of hematopoietic. We also evaluated the effects of overexpression of key molecules predicted to support the generation and maturation of HSCs. Among genes tested, we found that only SOX17 plays a critical role in priming hemogenic potential of endothelial cells.
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