Analysis of molecular mechanism in leukemogenesis through an epigenome regulator
Project/Area Number |
24591390
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Mie University |
Principal Investigator |
ONO RYOICHI 三重大学, 医学(系)研究科(研究院), 講師 (40422414)
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Co-Investigator(Renkei-kenkyūsha) |
NOSAKA Tetsuya 三重大学, 大学院医学系研究科, 教授 (30218309)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 白血病 / エピゲノム |
Outline of Final Research Achievements |
In this study, to focus on epigenetic alterations closely associated with leukemogenesis, I have generated conditional knockout mice of an epigenome regulator, analyzed malignant hematopoiesis of these mice combined with my leukemogenic mouse model, and characterized normal hematopoiesis of the mice. Conditional ablation of the target molecule induced no critical phenotypic changes in leukemogenesis, but led to interesting findings concerning self-renewal and differentiation of hematopoietic stem cells. I am further investigating the molecular mechanisms at the moment.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013
Author(s)
Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
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Journal Title
Exp Hematol
Volume: -
Issue: 4
Pages: 367-376
DOI
Related Report
Peer Reviewed
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