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Analysis of clonal hierarchy and microenvironment of the tumor developed in the mouse mantle cell lymphoma model

Research Project

Project/Area Number 24591391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKyoto University

Principal Investigator

NISHIKORI Momoko  京都大学, 医学(系)研究科(研究院), 助教 (60378635)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性リンパ腫 / マウスモデル / BCL2 / CyclinD1 / Cyclin D1
Outline of Final Research Achievements

Malignant lymphoma is classified into many histologic subtypes. They exhibit their own biological features that are shaped during their differentiation and maturation steps of lymphocytes in vivo. In this study, we have generated mouse lymphoma models that are triggered by CCND1 and BCL2 overexpression, and compared phenotypic and genotypic features of these tumors. We have found several important biological mechanisms on lymphoma histology determination that are considered common to humans.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Invited: 4 results) Remarks (2 results)

  • [Journal Article] Ki-67 is a strong predictor of central nervous system relapse in patients with mantle cell lymphoma (MCL).2015

    • Author(s)
      Chihara D, Asano N, Ohmachi K, Nishikori M, Okamoto M, Sawa M, Sakai R, Okoshi Y, Tsukamoto N, Yakushijin Y, Nakamura S, Kinoshita T, Ogura M, Suzuki R.
    • Journal Title

      Ann Oncol.

      Volume: 未定 Issue: 5 Pages: 966-973

    • DOI

      10.1093/annonc/mdv074

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased number of peripheral CD8+ T cells but not eosinophils is associated with late-onset skin reactions caused by bendamustine.2015

    • Author(s)
      Nishikori M, Kitano T, Kobayashi M, Hishizawa M, Kitawaki T, Kondo T, Yamashita K, Kawabata H, Kadowaki N, Takei Y, Haga H, Takaori-Kondo A.
    • Journal Title

      Int J Hematol.

      Volume: 未定 Issue: 1 Pages: 53-58

    • DOI

      10.1007/s12185-015-1791-3

    • NAID

      120005674658

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular Pathogenesis of Follicular Lymphoma2014

    • Author(s)
      Kishimoto W, Nishikori M.
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 54 Issue: 1 Pages: 23-30

    • DOI

      10.3960/jslrt.54.23

    • NAID

      130004886472

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Clinical, Pathological and Genetic Characterization of Methotrexate-Associated Lymphoproliferative Disorders.2014

    • Author(s)
      Yamakawa N, Fujimoto M, Kawabata D, Terao C, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Yurugi K, Miura Y, Maekawa T, Saji H, Matsuda F, Haga H, Mimori T
    • Journal Title

      J Rheumatol

      Volume: 41 Issue: 2 Pages: 293-299

    • DOI

      10.3899/jrheum.130270

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis.2013

    • Author(s)
      Yoshida N, et al
    • Journal Title

      Br J Haematol.

      Volume: 161 Issue: 2 Pages: 214-223

    • DOI

      10.1111/bjh.12255

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] B細胞リンパ腫における染色体転座の意義2013

    • Author(s)
      錦織 桃子
    • Journal Title

      臨床血液

      Volume: 54 Pages: 234-241

    • NAID

      10031196323

    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of Tim-1 and Its Pathogenetic Role in Primary CNS Lymphoma.2014

    • Author(s)
      Kishimoto W, Nishikori M, Arima H, Shirakawa K, Kitawaki T, Takaori-Kondo A.
    • Organizer
      56th ASH Annual Meeting and Exposition
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2014-12-06 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ki-67 Is a Strong Predictor for Central Nervous System Relapse in Patients with Mantle Cell Lymphoma (MCL).2014

    • Author(s)
      Chihara D, Asano N, Ohmachi K, Nishikori M, Okamoto M, Sawa M, Sakai R, Okoshi Y, Tsukamoto N, Yakushijin Y, Nakamura S, Kinoshita T, Ogura M, Suzuki R.
    • Organizer
      56th ASH Annual Meeting and Exposition
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2014-12-06 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expression of AID in neoplastic cells correlates with disease severity and worse outcome of DLBCL.2014

    • Author(s)
      Arima H, Fujimoto M, Kishimoto W, Nishikori M, Hishizawa M, Kitano T, Kondo T, Kadowaki N, Haga H, Akifumi-Takaori K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expression of Tim-1 and its pathogenetic role in primary CNS lymphoma.2014

    • Author(s)
      Kishimoto W, Nishikori M, Arima H, Shirakawa K, Kitawaki T, Takaori-Kondo A.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2015-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] B細胞性リンパ腫の臨床像と分子病態2014

    • Author(s)
      錦織 桃子
    • Organizer
      第54回日本リンパ網内系学会総会
    • Place of Presentation
      山形
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The isotype of the B-cell receptor in patients with follicular lymphoma.2014

    • Author(s)
      岸本渉、田嶌政治、有馬浩史、錦織桃子、北野俊行、高折晃史
    • Organizer
      第54回日本リンパ網内系学会総会
    • Place of Presentation
      山形
    • Year and Date
      2014-06-19 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低悪性度非ホジキンリンパ腫治療の新展開. シンポジウム2 :造血器腫瘍の治療法の新展開2013

    • Author(s)
      錦織 桃子
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] B細胞リンパ腫における染色体転座の意義2013

    • Author(s)
      錦織 桃子
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 薬剤性心腎機能障害とCMV網膜炎を伴った難治性濾胞性リンパ腫に対し臍帯血ミニ移植を実施し寛解を維持している一例2013

    • Author(s)
      河田岳人、錦織桃子、志村和穂、北野俊行、近藤忠一、門脇則光、高折晃史
    • Organizer
      第53回日本リンパ網内系学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Allogeneic HSCT for recurrent/refractory follicular lymphoma in a single institution.2013

    • Author(s)
      Tashima M, Kondo T, Kitano T, Maeda T, Nishikori M, Yamashita K, Kadowaki N, Takaori-Kondo A.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] The isotype of the B-cell receptor predicts survival of patients with DLBCL treated with R-CHOP.2013

    • Author(s)
      Arima H. Kitano T, Maeda T, Nishikori M, Kondo T, Kadowaki N, Takaori-Kondo A.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Establishment of a mouse model for mantle cell lymphoma.2012

    • Author(s)
      岸本渉、錦織桃子、田嶌政治、山本玲、坂井智美、都築忍、瀬戸加大、高折晃史
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] A murine model for eludicating the mechanism of lymphoma subtype determination.2012

    • Author(s)
      錦織桃子、田嶌政治、岸本渉、高折晃史
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Deregulation of CCND1 or BCL2 in immature B-cell stage determines the resulting lymphoma histology.2012

    • Author(s)
      田嶌政治、錦織桃子、岸本渉、山本玲、坂井智美、都築忍、瀬戸加大、高折晃史
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Deregulation of CCND1 or BCL2 in immature B-cell stage determines the resulting lymphoma histology.2012

    • Author(s)
      田嶌政治、錦織桃子、岸本渉、山本玲、坂井智美、大森勝之、都築忍、瀬戸加大、高折晃史
    • Organizer
      The 54th ASH Annual Meeting and Exposition
    • Place of Presentation
      米国 アトランタ
    • Related Report
      2012 Research-status Report
  • [Remarks] 京都大学大学院医学研究科 血液・腫瘍内科学 リンパ腫研究

    • URL

      http://www.kuhp.kyoto-u.ac.jp/̃hemonc/research/lymphoma.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 京都大学大学院医学研究科 血液・腫瘍内科学 リンパ腫研究

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~hemonc/research/lymphoma.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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