Development of a novel treatment for leukemia using axon guidance molecules

• Project/Area Number: 24591396
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: MATSUOKA HIROSHI (2015) 神戸大学, 医学(系)研究科(研究院), 准教授 (50418878)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 白血病 / 神経軸索ガイダンス分子 / 白血病幹細胞

Outline of Final Research Achievements

We screened for expression of axon guidance molecules in hematological malignant cells and we could finally focus on a molecule. We analyzed the function of the molecule and searched for the functional domain of the molecule in order to reach drug development.