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Cell targeting therapy for acute myeloid leukemia

Research Project

Project/Area Number 24591403
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionSapporo Medical University

Principal Investigator

TAKIMOTO Rishu  札幌医科大学, 医学部, 准教授 (10336399)

Co-Investigator(Kenkyū-buntansha) KATO Junji  札幌医科大学, 医学部, 教授 (20244345)
KOBUNE Masayoshi  札幌医科大学, 医学部, 准教授 (90336389)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
KeywordsAML / fucose / DDS / 白血病 / 細胞標的療法 / 急性骨髄性白血病 / ナノキャリア / フコース
Outline of Final Research Achievements

Acute myelogenous leukemia (AML) will achieve complete remission by induction therapy due to improvements in supportive and optimization therapy. In order to improve treatment efficacy by anti cancer drugs, specificity of drugs to leukemic cells should be important to ameliorate prognosis, since maximum dose of chemotherapeutic agents might be administered to AML patients, expecting less toxicity and more efficacy. We targeted AML cells utilizing fucose-bound liposome, since we found AML cells actively uptake L-fucose. Herein we report that intravenously injected L-fucose-bound liposomes containing daunorubicin can be successfully delivered to AML cells. This resulted in efficient tumor growth inhibition as well as prolonged survival in tumor-bearing mice. Thus, biological targeting utilizing characteristics of AML cells by fucose-bound liposome could be a promising new strategy for AML treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Increased duodenal iron absorption through upregulation of DMT1 due to enhancement of IRP1 activity in patients with NASH.2015

    • Author(s)
      Hoki T, Miyanishi K, Kato J, et al.
    • Journal Title

      Hepatology

      Volume: 印刷中 Issue: 3 Pages: 751-761

    • DOI

      10.1002/hep.27774

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells2014

    • Author(s)
      Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, Okagawa Y, Uemura N, Arihara Y, Murase K, Kawano Y, Iyama S, Takada K, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
    • Journal Title

      Gastric Cancer

      Volume: 23 Issue: 1 Pages: 85-97

    • DOI

      10.1007/s10120-014-0454-z

    • NAID

      40020700032

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel strategy inducing autophagic cell death in Burkitt’s lymphoma cells with anti-CD19-targeted liposomal rapamycin.2014

    • Author(s)
      Ono K, Sato T, Iyama S, Tatekoshi A, Hashimoto A, Kamihara Y, Horiguchi H, Kikuchi S, Kawano Y,Takada K, Hayashi T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kato J.
    • Journal Title

      Blood Cancer J

      Volume: 7 Issue: 2 Pages: e180-e180

    • DOI

      10.1038/bcj.2014.2

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fucosylated TGF-ß receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.2014

    • Author(s)
      Hirakawa M, Takimoto R, Tamura F, Yoshida M, Ono M, Murase K, Sato Y, Osuga T, Sato T, Iyama S, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
    • Journal Title

      Br J Cancer

      Volume: 110 Issue: 1 Pages: 156-163

    • DOI

      10.1038/bjc.2013.699

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.2013

    • Author(s)
      Ishiwatari H, Sato Y, Murase K, Yoneda A, Fujita R, Nishita H, Birukawa NK, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kobune M, Ota S, Kimura Y, Hirata K, Kato J, Niitsu Y.
    • Journal Title

      Gut

      Volume: 62(9) Issue: 9 Pages: 1328-39

    • DOI

      10.1136/gutjnl-2011-301746

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker.2013

    • Author(s)
      Hirakawa M, Sato Y, Takimoto R, Kobune M, Hirata K, Kato J, et al.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 71 Pages: 789-797

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.2013

    • Author(s)
      Tanaka S, Miyanishi K, Kobune M, Takimoto R, Kato J, et al.
    • Journal Title

      J Gastroenterol.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.2012

    • Author(s)
      Ishiwatari H, Sato Y, Murase K, Yoneda A, Fujita R, Nishita H, Birukawa NK, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kato J, Niitsu Y.
    • Journal Title

      Gut.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach.2012

    • Author(s)
      Yoshida M, Takimoto R, Murase K, Sato Y, Hirakawa M, Tamura F, Sato T, Iyama S, Osuga T, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
    • Journal Title

      PLoS One

      Volume: 7(7) Issue: 7 Pages: e39545-e39545

    • DOI

      10.1371/journal.pone.0039545

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Targeting Pancreatic Cancer Stem Like Cells Using a Nanoparticle Modified by L-Fucose.2013

    • Author(s)
      Takimoto R,Yoshida M,Murase K,Sato Y,Hirakawa M,Tamura F,Sato T,Osuga T,Miyanishi K,Takada K,Hayash T,Kobune M,Kato J
    • Organizer
      The American Association for the Study of Liver Diseases-Digestive Disease Week
    • Place of Presentation
      Orlando, U.S.A.
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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